Early Career Travel Awardees 2016

SFRR-Europe Early Career Investigator Travel Awards are sponsored by Elsevier on behalf of FRBM and Redox Biology, and are awarded to Early Career Investigators to cover travel and accommodation expenses during a short research stay in another laboratory in Europe.

RAÚL GONZÁLEZ OJEDA

Abbreviated CV
Raul Gonzalez Ojeda was born in Cordoba, Spain, in 1978. He graduated in Biology at the University of Cordoba, and obtained his PhD in 2011 doing a Doctoral Thesis on the antioxidant treatment against to oxidative stress and cell death in cultured human hepatocytes supervised by Dr. Jordi Muntane Relat. During the Doctoral phase he has realized various scientific stays in the Institut National de la Sante et de la Recherche Medicale (INSERM U-632, Montpellier, France) and Immunology Department in La Princesa University Hospital (Madrid, Spain). Between the years 2012-2015 he worked in Biochemistry Department of Cordoba University in the proteomic analysis of different proteins related to intracellular signaling pathways in vitro and in vivo study models. Nowadays, he has a Research Postdoctoral Contract Juan de la Cierva de Formacion in the group "Surgical Oncology, Regenerative Medicine y Cell Therapy” of the Biomedicine Institute of Seville (IBIS). Where he takes part in the research of the regulation of cell death and proliferation and its relationship with the therapeutic effectiveness on the hepatocellular carcinoma, the evaluation of the therapeutic effectiveness of Sorafenib and immunosuppression in the hepatocellular carcinoma (HCC), and the search of biomarkers in the cholangiocarcinoma. He has published about 30 papers included in the Journal of Citations Reports on effect of antioxidants on liver damage with in vivo and in vitro approaches, post-translational modifications in different proteins involved in cell death and signaling pathway, and study of different strategies against liver damage as HCC and cholangiocarcinoma.  

 

 

 

 MARTIN HUGO


Department of Molecular Toxicology
German Institute of Human Nutrition
Arthur-Scheunert-Allee 114-116
14558 Nuthetal, Germany
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Abbreviated CV

Martín Hugo was born in Nueva Helvecia, Uruguay, in 1984. He graduated in Biochemistry at Universidad de la República and obtained his PhD in Biological Sciences in 2014 doing a doctoral thesis on enzymes involved in the detoxification of reactive oxygen species in intracellular pathogens, under the supervision Prof. Rafael Radi and Madia Trujillo. During his thesis, a novel subfamily of peroxiredoxins present in Mycobacterium tuberculosis, specialized in the detoxification of lipid hydroperoxides was described, and a novel mycothiol-dependent pathway for the reduction of the enzyme was found. In Trypanosoma cruzi, a novel function and subcellular localization of a heme peroxidase with relevance in parasite virulence was discovered. His main research interests are the mechanisms of cysteine modification and its role in enzyme regulation. In 2014 he joined the Molecular Toxicology group headed by Prof. Tilman Grune at the German Institute of Human Nutrition where he is currently applying cysteine-targeted proteomics to understand the regulation of the proteasomal system by cysteine modification in pancreatic b-cells. He received the SFRR-E Early Career Investigator Award 2016 sponsored by Elsevier on behalf of FRBM to support his travel and stay in the laboratory of Dr. Antonio Martínez-Ruiz in the Princesa Health Research Institute as host institution.

Selected publications
Hugo M, Martínez A, Trujillo M, Estrada D, Mastrogiovani M, Linares E, Augusto O, Issoglio F, Zeida A, Estrín D, Heijnen HFG, Piacenza L, Radi, R. Kinetics, subcellular localization and contribution to parasite virulence of a Trypanosoma cruzi hybrid type A heme peroxidase (TcAPx-CcP). PNAS 2017
Randall LM, Manta B, Hugo M, Gil M, Batthyàny C, Trujillo M, Poole LB, Denicola A. Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase. J Biol Chem. 2014
Martinez A, Peluffo G, Petruk AA, Hugo M, Piñeyro D, Demicheli V, Moreno DM, Lima A, Batthyány C, Durán R, Robello C, Martí MA, Larrieux N, Buschiazzo A, Trujillo M, Radi R, Piacenza L. Structural and molecular basis of the peroxynitrite-mediated nitration and inactivation of Trypanosoma cruzi iron-superoxide dismutases (Fe-SODs) A and B: disparate susceptibilities due to the repair of Tyr35 radical by Cys83 in Fe-SODB through intramolecular electron transfer. J Biol Chem. 2014
Hugo M, Van Laer K, Reyes AM, Vertommen D, Messens J, Radi R, Trujillo M. Mycothiol/mycoredoxin 1-dependent reduction of the peroxiredoxin AhpE from Mycobacterium tuberculosis. J Biol Chem. 2014
Reyes AM, Hugo M, Trostchansky A, Capece L, Radi R, Trujillo M. Oxidizing substrate specificity of Mycobacterium tuberculosis alkyl hydroperoxide reductase E: kinetics and mechanisms of oxidation and overoxidation. Free Radic Biol Med. 2011
Hugo M, Turell L, Manta B, Botti H, Monteiro G, Netto LE, Alvarez B, Radi R, Trujillo M. Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics. Biochemistry. 2009  

The Society for Free Radical Research - Europe (SFRR-E) is dedicated to promoting interest in all aspects of of research related to Free Radicals in any scientific field.

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