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RESEARCH POSITION

Institute of Molecular Biology (Mainz, Germany)

PhD position in biochemistry - Redox biology in the cardiovascular system

With the present proposal we suggest to use animal models with reduced or increased ROS formation (e.g. p47phox-/- and Cu,Zn-SOD-/- mice) along with clinically relevant oxidative stress challenges (e.g. pharmacologically- or genetically-induced hypertension, diabetes, obesity) in order to identify novel “redox switches” in epigenetic pathways

https://www.imb.de/students-postdocs/international-phd-programme/apply-to-ipp/

Date: October 31, 2016

Situation: Open

Recruiter: Professor Andreas Daiber

Starting date: 1 March 2017 or later
Deadline for applications (exclusively online via web form): 10 November 2016

Mainz (Germany)

Crosstalk between DNA damage checkpoints and nutrient signalling

With regards to the non-coding RNA TERRA, we are using yeast and human cells to understand how RNA-DNA hybrids (R-loops) are regulated at telomeres throughout the cell cycle and also in cells that have escaped senescence (similar to cancer cells using the ALT mechanism). We are employing live cell microscopy, chromatin immunoprecipitation, Southern blotting and many other molecular, genetic and biochemical assays to address these questions. We believe that a better understanding of TERRA regulation could eventually provide a specific means to target ALT cancers.

http://www.jobvector.de/jobs-stellenangebote/biologie-life-sciences/forschung-entwicklung/phd-position-in-telomere-biology-80242.html

Recruiter: Dr Brian Luke

Starting date: 1 March 2017 or later
Deadline for applications (exclusively online via web form): 10 November 2016

Leibniz Institute on Aging – Fritz Lipmann Institute e. V. (FLI) (JENA, Germany)

Postdoc / PhD position - Organ Maintenance in Aging

The Leibniz Institute on Aging - Fritz Lipmann Institute e.V. (FLI) is a research institute, which has the objective of understanding the molecular mechanisms of aging. Thereby we would like to contribute to healthy aging in humans. Various animal models (e.g. mice and fish) help us to generate relevant knowledge on the causes and the mechanisms of age-associated diseases and to investigate new therapeutic approaches. Scientists from many different nations conduct research at FLI.

http://academicpositions.co.uk/ad/leibniz-institute-age-research-fritz-lipmann-institute-fli/2016/postdoc-phd-position-organ-maintenance-in-aging/93471

http://www.leibniz-fli.de/research/research-groups/englert/

Recruiter: Christoph Englert (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Published: 2016-10-24

Application deadline: 2016-11-15

Ludwig-Maximilians-University (LMU) (Munich, Germany)

Analysis of the role of the p53-inducible 14-3-3sigma in epidermal and intestinal tumor suppression in mouse models

We are interested in understanding the role of p53 regulated in the suppression of intestinal and skin cancer. p53 is the most commonly mutated tumor suppressor gene and encodes a transcription factor that activates target genes, which mediate the effects of p53. In the past we have identified and characterized several p53 target genes, such as 14-3-3sigma and miR-34a.

http://www.pathologie.med.uni-muenchen.de/020wissenschaft/009ag_hermeking/engl_ag_hermeking/index.html

Published: 2016-10-20

Application deadline: 2016-11-03

Recruiter: Prof. Heiko Hermeking. Experimental and Molecular Pathology. Institute of Pathology. Ludwig-Maximilians-Universität München (Munich, Germany). e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

University of East Anglia (Norwich Research Park, UK)

Exploring the “hidden” intracellular cysteine thiol pool

In humans, the cysteine-containing tripeptide glutathione (GSH) is an essential thiol cofactor that maintains an intracellular reducing environment to protect against oxidative stress reactive oxygen species, which cause lipid, protein & DNA damage. In diabetics, many of the long term complications arising from high glucose levels stem from elevated levels of glycolytic intermediates (DHAP and GAP) causing oxidative stress and lowering the levels of glutathione and cysteine

http://jobs.sciencecareers.org/job/430706/exploring-the-hidden-intracellular-cysteine-thiol-pool-hamilton_u17dtp-/

http://www.biodtp.norwichresearchpark.ac.uk/contact

www.biodtp.norwichresearchpark.ac.uk

Candidates will be interviewed on either the 10th, 11th or 12th January 2017

Understanding variation of iron-sulfur cluster type and coordination within a single regulatory protein

The Rrf2 family of regulators is widespread amongst bacteria and control some of the most important cellular pathways, including iron metabolism, iron-sulfur biogenesis and the response to oxidative and nitrosative stress. Many Rrf2 family regulators bind an iron-sulfur cluster, and this is the key sensory module of the regulator. It turns out that although Rrf2 proteins are very similar to one another, the type of cluster they bind, and the way that they do it, varies from one family protein to another. This project is focused on determining cluster type and coordination and understanding the important factors that control these characteristics.

http://jobs.sciencecareers.org/job/430692/understanding-variation-of-iron-sulfur-cluster-type-and-coordination-within-a-single-regulatory-p-/

Candidates will be interviewed on either the 10th, 11th or 12th January 2017.

University of Southampton, United Kingdom

The University of Southampton Faculty Of Medicine is offering an appointment to be based within the Cancer Research UK/ Experimental Cancer Medicine Centre (ECMC) Centre at Southampton General Hospital. The post-holder will join a large team of basic and clinical researchers with extensive programmes in translational cancer medicine.

Location: Southampton General Hospital
Salary: £32,156 to £43,868 per annum
Full Time Fixed Term
Closing Date: Monday 07 November 2016

You should submit your completed online application form at www.jobs.soton.ac.uk. The application deadline will be midnight on the closing date stated above. If you need any assistance, please call Jennifer Dickson (Recruitment Team) on 44 (0) 23 8059 3462. Please quote reference 790216CM on all correspondence.

The Society for Free Radical Research - Europe (SFRR-E) is dedicated to promoting interest in all aspects of of research related to Free Radicals in any scientific field.

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