Dear colleagues, 

We are celebrating our birthday! It’s already been 3 years since the formation of the ECR subcommittee! We are very happy to reflect on what we have achieved so far for early career researchers, and we thank you all for the support that you have shown to us along the way. For more years to come!

In today's newsletter, we will do a sum-up of how much the ECR subcommittee has grown its first three years. We will also announce the upcoming March’s webinar discussing redox, exercise and nutrition and share with you a summary of February’s webinar. At the end of the newsletter, as always, you can also find a collection of upcoming events with important deadlines, some suggestions of interesting redox reads recently published, open call for papers and job opportunities for young redox researchers.

Three years of the ECR subcommittee: what we have achieved so far!

It seems like yesterday when this exciting journey of creating an ECR subcommittee composed by early career researchers and for early career researchers began. And look at us now! It’s been three years of intense work, networking and learning. This is what we have achieved so far:

• Webinar series: On the 7^th February 2022, we launched our webinar series “Emerging leaders in redox biology”. So far we’ve organised 19 webinars on a wide variety of topics: from NADPH oxidases to persulfides, from aging to exercise, from peer review to mental health. We are delighted to see the great reception these webinars have had, and we are already working in the next edition!
  
  
• Social media: We have created accounts on different platforms. Many of you follow us on our fun and creative Instagram account (https://www.instagram.com/sfrr_ecr/), so far we have 1026 followers! Some of you are more into the professional-oriented LinkedIn where we already have 378 followers (https://www.linkedin.com/company/sfrr-e-ecr/)! Or maybe you prefer our X account that counts 946 followers. However we are transitioning to Bluesky, so please follow us there (https://bsky.app/profile/sfrre-ecr.bsky.social)!
  
  
• SFRR-E meetings: Starting in Ghent 2022, we have had the opportunity to organise some activities at the annual SFRR-Europe conferences. Thanks to your participation and interest in these events, we’ve been gradually increasing the number of activities that we plan. Last year in Istanbul we organised a successful ECR networking event, a meet the professor session, two sunrise seminars and the first ECR symposium with only young speakers! We will soon announce what we have planned for Galway conference, but you can check the schedule for some hints https://www.sfrrgalway2025.com/ 
  
  
• Mentoring program: In 2023 we created a mentoring program in which we paired young scientists with senior scientists to get career and professional advice. We have run this program now for two cohorts and organised the first mentoring lunch at Istanbul’s conference last year. We are over the moon with your positive experiences, knowing that it is helping you grow makes all the efforts worth it! We are happy to announce that the program will run for a third year, stay tuned!
  
  
• Editorial mentoring program: We created a new editorial mentoring program in which selected young scientists are paired with an editor of the best redox journals for a year to learn how editorial work functions. The program is now running and the first cohort is getting hands-on experience.

The ECR subcommittee works very hard to deliver all these. We are very pleased that our efforts are so well appreciated and we are very thankful for all the feedback and the support you have given us. Recently FEBS asked us to write a piece about our work highlighting our achievements. You can see it here: https://network.febs.org/posts/what-is-the-ecr-subcommittee-of-the-sfrr-europe-up-to-the-new-kid-on-the-block 

Next Webinar series “Emerging leaders in redox biology”

The next webinar of the year will take place on March 4th, 2025, at 15:00 CET, focusing on the hot topic “H₂S redox signaling” with featured speakers Stephen Bailey, Edziu Franczak and Lewan Parker. 

Influence of dietary nitrate supplementation on skeletal muscle redox processes, physiological responses and exercise performance

Stephen Bailey, PhD

Loughborough University, UK

Stephen’s research focuses on exercise and nutritional interventions to improve nitric oxide production, cardiovascular health, oxidative metabolism and exercise performance.  Stephen has published over 150 research outputs on these topics.  He is a Fellow of the European College of Sport Science, a member of The Physiological Society, and he serves on the editorial board of two international journals and as a judge for the European Specialists Sports Nutrition Awards.

Mitochondrial quality control: Another reason why women are superior

Edziu Franczak, PhD candidate

University of Kansas Medical Center, Kansas, USA

Edziu is a PhD student in Dr. John Thyfault's lab at the University of Kansas Medical Center. His research focuses on understanding the mechanisms that regulate the pathogenesis and treatment of metabolic dysfunction-associated steatotic liver disease (MASLD) in the context of exercise and dietary metabolic stressors. Specifically, his research aims to understand how estrogen-mediated signaling modulates hepatic mitochondrial respiratory capacity and quality control mechanisms that may foster innate protection against MASLD in female rodent models. 

The effect of exercise and nutrient ingestion on biomarkers of redox homeostasis

Lewan Parker, PhD

Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Australia

Dr Parker is a joint NHMRC & Heart Foundation Early Career Fellow and leader of the Redox Regulation of Health and Disease research group at Deakin’s Institute for Physical Activity and Nutrition (IPAN). Dr Parker's internationally recognised research program explores how physical activity, redox biology, bone metabolism, and vascular health, regulate glycaemic control, exercise capacity, and cardiometabolic health and disease. Through the identification of novel mechanisms, his research continues to explore new ways to harness exercise and nutrition for the prevention, management, and treatment of chronic diseases such as type 2 diabetes and cardiovascular disease.

Summary of February’s webinar:

On February's webinar we learnt about “H₂S redox signaling” with two inspiring talks by Denisse Scufi and Jan Miljkovic. If you didn’t have a chance to follow the webinar, here’s a summary for you. Remember that you can also watch the recordings of the webinars through the SFRR-E intranet. 

Hydrogen sulfide role in stomatal immunity

Denisse Scufi, PhD

Signaling Mechanisms in Plants Lab, IIB-CONICET-UNMdP, Mar Del Plata, Argentina

Shut the Pore! - Stomata are natural pores on the leaf surface that help plants exchange gases with the environment. Stomata also function as entry points for pathogens. Plants can regulate stomata closure by different molecular mechanisms, including phytohormones, hydrogen sulfide (H₂S), or the recognition of peptide effectors from the pathogen, among others. In this webinar, Dr. Denise Scuffi shared their latest work characterising the role of H₂S in the pathogen-induced stomata closure. This was evaluated using a mutant line in cytosolic L-CYSTEINE DESULFHIDRASE 1 (DES1), the main source of cytosolic H₂S in plants. They proved that stomata closure in des1 plants does not happen after exposition to either the pathogen or the effector. A response that can be reversed in des1 plants is treating these mutants with an H₂S donor. Moreover, they further conclude that the role of H2S in regulating stomata closure is also linked with the control of hydrogen peroxide (H₂O₂) and intracellular calcium homeostasis. We invite everyone to check Dr. Scuffi’s research in their latest preprint (https://doi.org/10.1101/2025.02.14.638267).

Mitochondria-Targeted Protection Against Cardiac Ischemia-Reperfusion via Rapid Persulfide and H2S Release

Jan Miljkovic, PhD

MRC Mitochondrial Biology Unit, University of Cambridge, UK

Hydrogen Sulfide to the Heart- In this webinar, Dr. Jan Miljkovic presented his work on creating, designing, and applying sulfur-containing molecules to treat the damage produced by cardiac ischemia reperfusion (IRI). These molecules act as hydrogen sulfide (H₂S) donors, which has been demonstrated to be beneficial for cardiac pathologies. The multiple roles of H₂S include scavenging ROS/RNS, binding to the metal centres of proteins, and promoting a post-translational modification called S-sulfhydration. In their novel approach, Dr. Miljkovic showed how a targeted delivery of H₂S from mitochondria, using targeted compounds that serve as H₂S donors, could represent a therapeutic opportunity to alleviate IRI. Among these compounds, using MitoPerSulf before IRI showed a significant cardioprotective effect in a mouse model, limiting the IRI-associated damage. These results show MitoPerSulf as a cardioprotective strategy with great potential against the damaging effects of IRI when applied in a precise time window before the tissues become ischemic. For more details, please check Dr. Miljkovic’s work published in Redox Biology (https://doi.org/10.1016/j.redox.2022.102429).

More information about the ECR Subcommittee can be found on the SFRR-E website (ECR Committee), while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: This email address is being protected from spambots. You need JavaScript enabled to view it..

Hope to see you online for our next Webinar Series appointment,

The ECR subcommittee

Upcoming events:

UK Redox Network Meeting

• 28 April 2025
• Location: London, UK

22nd SFRRI Biennial Meeting

• The New Era of Redox Biology: from Basic Biochemistry to Redox Omics
• 3 - 6 June 2025
• Location: Galway, Ireland
• Deadlines:
  • Travel Grant Applications: 10 January 2025
  • Abstract Submission: 10 February 2025
  • Early Bird Registration: 31 March 2025
• Further information: https://www.sfrrgalway2025.com

 FASEB Science Research Conference. Ferroptosis, Oxidative Stress, and Lipid Metabolism

• 27 - 31 July 2025
• Location: Scottsdale, Arizona
• Deadlines:
  • Abstract Submission: 1 June 2025
  • Early Registration: 15 June 2025
  • Housing: 13 July 2025
• Further information: https://events.faseb.org/event/11797f9e-df16-42b9-9c47-f1e06713c4fb/summary

EMBO Workshop: Thiol based redox switches: From chemistry to physiology and pathology

• 13 - 18 September 2025
• Location: Sant Feliu de Guixols, Spain
• Abstract Submission Deadline: 18 May 2025
• https://meetings.embo.org/event/25-thiol-switches

Interesting Redox Papers:

Cobley, J.N., Chatzinikolaou, P.N. & Schmidt, C.A. The nonlinear cysteine redox dynamics in the i-space: A proteoform-centric theory of redox regulation. Redox Biol (2025). https://doi.org/10.1016/j.redox.2025.103523

Zhang, Q., Liu, X. & Wei, Q. Apoptotic breast cancer cells after chemotherapy induce pro-tumour extracellular vesicles via LAP-competent macrophages. Redox Biol (2025). https://doi.org/10.1016/j.redox.2024.103485

Cendali, F.I., Lisk, C., Dzieciatkowska, M., et al. Increased exercise tolerance in humanized G6PD-deficient mice. Blood Adv (2025). https://doi.org/10.1182/bloodadvances.2024013968

Smiriglia, A., Lorito, N., Bacci, M., et al. Estrogen-dependent activation of TRX2 reverses oxidative stress and metabolic dysfunction associated with steatotic disease. Cell Death Dis (2025). https://doi.org/10.1038/s41419-025-07331-7

Li, H., Furusawa, T., Cavero, R., et al. Metabolic dependency mapping identifies Peroxiredoxin 1 as a driver of resistance to ATM inhibition. Redox Biol (2025). https://doi.org/10.1016/j.redox.2025.103503

Valeros, J., Jerome, M., Tseyang, T., et al. Rhodoquinone carries electrons in the mammalian electron transport chain. Cell (2025). https://doi.org/10.1016/j.cell.2024.12.007

Torres-López, M., Spiller, P.F., Gao, L., et al.. Acute oxygen sensing by arterial chemoreceptors with a mutant mitochondrial complex I ND6 subunit lacking reverse electron transport. FEBS Lett (2025). https://doi.org/10.1002/1873-3468.70017

Morton, K.S., George, A.J. & Meyer, J.N. Complex I superoxide anion production is necessary and sufficient for complex I inhibitor-induced dopaminergic neurodegeneration in Caenorhabditis elegans. Redox Biol (2025). https://doi.org/10.1016/j.redox.2025.103538

Petrovic, D., Slade, L., Paikopoulos, Y., et al. Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation. Cell Metab (2025). https://doi.org/10.1016/j.cmet.2024.12.008

Insightful Redox Reviews:

Liu, P., Liu, Z.Y., Mao, S., et al. Targeted mitochondrial function for cardiac fibrosis: An epigenetic perspective. Free Radic Biol Med (2025). https://doi.org/10.1016/j.freeradbiomed.2025.01.001

Chrzan, N. & Hartman, M.L. Copper in melanoma: At the crossroad of protumorigenic and anticancer roles. Redox Biol (2025). https://doi.org/10.1016/j.redox.2025.103552

Guo, Q., Tang, Y., Wang, S & Xia, X. Applications and enhancement strategies of ROS-based non-invasive therapies in cancer treatment. Redox Biol (2025). https://doi.org/10.1016/j.redox.2025.103515

Fuentes-Lemus, E., Usgame, K., Fierro, A. & López-Alarcón, C. Enzymes of glycolysis and the pentose phosphate pathway as targets of oxidants: Role of redox reactions on the carbohydrate catabolism. Redox Biochem Chem (2025). https://doi.org/10.1016/j.rbc.2025.100049 

Lastest Redox Preprints:

Lang, L., Leiskau, L., Thullen, L. & Deponte, M. H2S is a potential universal reducing agent for Prx6-type peroxiredoxins. BioRxiv (2025). https://doi.org/10.1101/2025.02.13.638076

Wyckelsma, V.L., Murgia, M., Kamandulis, S., et al. Antioxidant supplementation blunts the proteome response to three weeks of sprint interval training preferentially in human type 2 muscle fibres. BioRxiv (2025). https://doi.org/10.1101/2025.01.27.634979

Call for papers:

• Journal: Free Radical Biology and Medicine
• Special Issue: Redox medicine: Translation of Basic science to the Clinic
• Submission deadline: 1 March 2025
• More information: https://www.sciencedirect.com/special-issue/314690/redox-medicine-translation-of-basic-science-to-the-clinic

Redox Job Opportunities:

Remember that if there’s an open position in your lab for early career researchers and you would like to advertise it in our newsletter, just write us an email (This email address is being protected from spambots. You need JavaScript enabled to view it.) containing the following information:

• Kind of position: (PhD student, Postdoc, etc)
• Research topic
• Institute/University
• Deadline
• Contact information
• Further information about the position (if any)

Dear colleagues, 

Happy New Year!

We are wishing you a prosperous year, with exciting discoveries, important publications and progress and growth in your career! We are hoping to see you all in person in Galway in June this year for the SFRR-I meeting hosted by SFRR-E! Don’t forget to submit your abstract by the 10th of February!

In today's newsletter, we will present to you the first cohort of the Editorial Mentoring Programme. We will also announce the upcoming February’s webinar discussing H₂S redox signaling and share with you a summary of December’s and January’s webinar. At the end of the newsletter, as always, you can also find a collection of upcoming events with important deadlines, some suggestions of interesting redox reads recently published, open call for papers and job opportunities for young redox researchers.

The SFRR-E ECR Editorial mentoring programme is here!

We are delighted to announce that the ECR editorial mentoring programme is now underway!

The SFRR-E ECR committee with support from the SFRR-E, the SFRR-E official journals and Elsevier announced the launch of a new ECR editorial mentoring programme late last year. The aim of the programme is to offer Early Career Researchers (ECRs) the opportunity to increase their engagement with scientific publishing and gain experience in editorial board work and manuscript handling.

Seven selected mentees have now started working with Rafael Teixeira, receiving training information on the roles of editors and the Elsevier online system. When the training is completed, each mentee will start working with their mentor until the end of the year. The mentors on the programme are Andreas Daiber (Redox Biology), Giovanni Mann (FRBM) and Michael Davies (RBC).

We believe that the mentees will learn a lot from the vast expertise of the mentors and they will benefit tremendously from this experience. We are thankful to everybody who made this programme possible!

Next Webinar series “Emerging leaders in redox biology”

The next webinar of the year will take place on February 4th, 2025, at 15:00 CET, focusing on the hot topic “H₂S redox signaling” with featured speakers Denisse Scufi and Jan Miljkovic.

Hydrogen sulfide role in stomatal immunity

Denisse Scufi, PhD

Signaling Mechanisms in Plants Lab, IIB-CONICET-UNMdP, Mar Del Plata, Argentina

She is a researcher at Signaling Mechanisms in Plants Lab at the IIB-CONICET-UNMdP, Argentina. During her PhD she established the link between gasotransmitters and phospholipids in stomatal movements under Drs. García-Mata and Laxalt supervision. Furthermore, she visited the Plant Energy Biology Lab head of Dr. Schwarzländer in Germany where she trained in studying the dynamics of reactive oxygen species and redox regulation in living plant cells through novel fluorescent protein sensors. She is particularly focused on hydrogen sulfide (H₂S) involvement during stomatal immunity and the signalling behind it. Furthermore, she is interested in finding target proteins of the posttranslational modification (PTM) triggered by H₂S, known as persulfidation, and how this PTM modulates target proteins in the plant-pathogen context.

Mitochondria-Targeted Protection Against Cardiac Ischemia-Reperfusion via Rapid Persulfide and H₂S Release

Jan Miljkovic, PhD

MRC Mitochondrial Biology Unit, University of Cambridge, UK

He is a Senior Research Associate at the MRC Mitochondrial Biology Unit, University of Cambridge, UK. His research background, beginning with Ph.D. training, established expertise in gasotransmitters (e.g., NO, HNO, and H₂S) and redox-related mechanisms within cellular biology, particularly concerning reactive oxygen species and protein posttranslational modifications. Building on this foundation, his postdoctoral training expanded his focus to include the effects of dietary interventions, caloric restriction, and H₂S on metabolism and longevity, with an emphasis on their translational applications.

Currently, his work centres on H₂S-based regulation of mitochondrial and cellular metabolism, with the goal of developing novel therapeutics that advance lifespan research and enhance our understanding of redox regulation in both normal and altered cellular homeostasis.

Summary of December’s and January’s webinar:

On December's webinar we learnt about “Redox Methods” with two inspiring talks by James Cobley and Rafael Argüello while in January, the focus was on “Environmental stressors in cardiovascular diseases” and we enjoyed two great talks by Timoteo Marchini and Marin Kuntic. If you didn’t have a chance to follow the webinar, here’s a summary for you. Remember that you can also watch the recordings of the webinars through the SFRR-E intranet.

Oxiforms: Redox biology at the proteoform level

James Cobley, PhD

School of Life Sciences, University of Dundee, Dundee, United Kingdom

The talk provided a mathematical description of cysteine redox proteoforms, covering how they are distributed into percentage redox grades. Their geometry with respect to binomial theorem-Pascal’s triangle-was also delineated. Computational experiments suggest highly oxidised cysteine redox proteoforms might form in the context of redox regulation. A novel method called Cleland Immunoblotting confirmed that this might be the case, revealing unexpected cysteine redox proteoforms. This emerging area is expected to generate new insights in redox biology.

Decoding complexity: A closer look at stress, metabolism and epigenetic crosstalks through Epic-SCENITH and SNUPR

Rafael Argüello, PhD

Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France

Advancing personalized medicine through metabolic profiling. In our latest webinar, Rafael Argüello shared with us the critical need for personalized medicine to address the alarming 86% failure rate in conventional clinical trials. He emphasized how the future of personalized diagnosis relies on the identification of independent patient characteristics beyond superficial clinical data. By leveraging advanced metabolic profiling and comprehensive blood assays, His research aims to uncover deeper insights into individual patient biology, focused on the intricate nature of cellular metabolism using SCENITH, a groundbreaking, flow cytometry-based technique designed to profile energy metabolism at the single-cell level. SCENITH operates by blocking specific metabolic pathways to halt ATP production, allowing precise measurement of cellular responses using Seahorse technology. This method enables the detection of changes in protein synthesis and offers detailed metabolic profiles of diverse cell types. As an example, this method allows the analysis of myeloid cells within solid tumors such as meningioma and renal carcinoma. The technique reveals varied metabolic profiles that are independent of cell lineage or activation states, providing essential data for understanding tumor microenvironments and immune responses. Additionally, SCENITH is optimized for ex vivo studies, particularly beneficial for rare cells in whole blood samples, thereby minimizing biases introduced by culture media.

Redox and inflammatory mechanisms linking air pollution PM2.5 exposure with cardiovascular disease and metabolic derangements

Timoteo Marchini, PhD

Vascular Immunology Laboratory, Department of Cardiology and Angiology, University Medical Center, Freiburg, Germany

Leave the car and use the bike – Dr. Timoteo Marchini shared with us his research focused on how cardiovascular and respiratory health is affected by air pollution, specifically the fine particulate matter (PM2.5) that comes from fossil fuel combustion. These particles reach deep into the lungs, initiating oxidative stress and inflammation, which aggravates myocardial infarction and stroke, accelerates atherosclerosis, and promotes cardiovascular risk factor development (e.g., obesity). Their experimental approach uses collected PM2.5 samples in vitro and in vivo (acute) settings, as well as chronic models of whole-body exposure to polluted urban air. These models revealed early markers of lung inflammation, such as increased leukocyte counts and pro-inflammatory cytokine release driven by preceding rises in oxidized glutathione levels. Dr. Marchini described how chronic urban air exposure in mice causes pulmonary inflammation and impaired cardiac mitochondrial function. Alterations that contribute to greater myocardial damage following ischemia-reperfusion injury. They managed to pinpoint that the NLRP3 inflammasome in macrophages is activated by PM2.5 through lysosomal disruption and mitochondrial dysfunction, leading to the release of IL-1β.

Effects of combined exposure to noise and particulate matter

Marin Kuntic, PhD

Johannes Gutenberg University Medical Center, Mainz, Germany

It’s a pollutant? It’s a plane? – Dr. Marin Kuntic presented his research on how air and noise pollution affect us, with a focus on aircraft noise and its impact on cardiovascular health. Noise pollution is more than just an annoyance and it constitutes a serious public health risk that affects a portion of the European population. Importantly, Dr. Kuntic’s research uncovered that sustained noise exposure is linked to markers of oxidative stress and endothelial dysfunction, critical precursors to cardiovascular complications. Using a mouse model, they study h ow cardiovascular drugs might mitigate these adverse effects. Mice exposed to aircraft noise were treated with a combination of the beta-blocker propranolol and the alpha-blocker phenoxybenzamine. These compounds effectively prevented noise-induced endothelial and microvascular dysfunction, suggesting potential pathways to safeguard human cardiovascular health against environmental stressors.

More information about the ECR Subcommittee can be found on the SFRR-E website https://www.sfrr-europe.org/index.php/ecr-committee , while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: This email address is being protected from spambots. You need JavaScript enabled to view it..

Hope to see you online for our next Webinar Series appointment,

The ECR subcommittee

Upcoming events:

22nd SFRRI Biennial Meeting

• The New Era of Redox Biology: from Basic Biochemistry to Redox Omics
• 3 - 6 June 2025
• Location: Galway, Ireland
• Deadlines:
  • Travel Grant Applications: 10 January 2025
  • Abstract Submission: 10 February 2025
  • Early Bird Registration: 31 March 2025
• Further information: https://www.sfrrgalway2025.com

FASEB Science Research Conference. Ferroptosis, Oxidative Stress, and Lipid Metabolism

• 27 - 31 July 2025
• Location: Scottsdale, Arizona
• Deadlines:
  • Abstract Submission: 1 June 2025
  • Early Registration: 15 June 2025
  • Housing: 13 July 2025
• Further information: https://events.faseb.org/event/11797f9e-df16-42b9-9c47-f1e06713c4fb/summary

Interesting Redox Papers:

Scherschel, M., Niemeier, J-O., Jacobs, L.J.H.C., et al. A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes. Nat Comm (2024). https://doi.org/10.1038/s41467-024-55302-x

Ostrom, E.L., Stuppard, R., Mattson-Hughes, A. & Marcinek, D.J. Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibility. Free Radic Biol Med (2025). https://doi.org/10.1016/j.freeradbiomed.2024.10.310 

Zimmermann, J., Lang, L., Calabrese, G., et al. Tsa1 is the dominant peroxide scavenger and a source of H2O2-dependent GSSG production in yeast. Free Radic Biol Med (2025). https://doi.org/10.1016/j.freeradbiomed.2024.11.004

Obermann, T., Sakshaug , T., Kanagaraj , V.V., et al. Genomic 8-oxoguanine modulates gene transcription independent of its repair by DNA glycosylases OGG1 and MUTYH. Redox Biol (2025). https://doi.org/10.1016/j.redox.2024.103461

Zhang, Q.Y., Zhang, H.Y., Feng, S.G., et al. Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction. Redox Biol (2025). https://doi.org/10.1016/j.redox.2024.103449

Eaglesfield, R., Fernandez-Vizarra, E., Lacko, E., et al. Sub-organellar mitochondrial hydrogen peroxide observed using a SNAP tag targeted coumarin-based fluorescent reporter. Redox Biol (2025). https://doi.org/10.1016/j.redox.2025.103502

Shields, S., Gregory, E., Wilkes, O., et al. Oxidative Stress Promotes Axonal Atrophy through Alterations in Microtubules and EB1 Function. Aging Dis (2025). https://doi.org/10.14336/AD.2024.0839

Insightful Redox Reviews:

Fujii, J., Ochi, H. & Yamada, S. A comprehensive review of peroxiredoxin 4, a redox protein evolved in oxidative protein folding coupled with hydrogen peroxide detoxification. Free Radic Biol Med (2025). https://doi.org/10.1016/j.freeradbiomed.2024.12.015

Matrullo, G., Filomeni, G. et Rizza, S. Redox regulation of focal adhesions. Redox Biol (2025). https://doi.org/10.1016/j.redox.2025.103514 

Rojo, A.I., Buttari, B., Cadenas, S., et al. Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases. Redox Biol (2025). https://doi.org/10.1016/j.redox.2024.103464

Ghosal, J., Sinchana, V.K. & Chakrabarty, S. Ferroptosis meets microRNAs: A new frontier in anti-cancer therapy. Free Radic Biol Med (2025). https://doi.org/10.1016/j.freeradbiomed.2024.11.023

Huang, H., Chen, Y., Xu, W. et al. Decoding aging clocks: New insights from metabolomics. Cell Metab (2025). https://doi.org/10.1016/j.cmet.2024.11.007

Call for papers:

• Journal: Free Radical Biology and Medicine
• Special Issue: Redox medicine: Translation of Basic science to the Clinic
• Submission deadline: 1 March 2025
• More information:
• https://www.sciencedirect.com/special-issue/314690/redox-medicine-translation-of-basic-science-to-the-clinic 

Redox Job Opportunities:

Postdoc positions

• Kind of position: Postdoc (2 years)
• Research topic: Physiology and Pharmacology
• Institute/University: Karolinska Institute, Stockholm
• Deadline: 31st January 2025
• Contact information: This email address is being protected from spambots. You need JavaScript enabled to view it.
• Further information about the position: We are searching for someone skilled in biochemistry and/or chemical biology. Knowledge in EPR technique is highly appreciated.

PhD positions

• Kind of position: PhD position (4 years)
• Research topic: Understanding intracellular redox heterogeneity
• Institute/University: The University of Liverpool
• Deadline: 31 January 2025
• Contact information: This email address is being protected from spambots. You need JavaScript enabled to view it.
• Further information about the position: A PhD position (fully funded for UK students only) is available at the lab of Dr P. Kritsiligkou. Please contact them directly for more information on how to apply.

• Kind of position: PhD position (4 years)
• Research topic: RNA modifications under stress conditions
• Deadline: 31 January 2025
• Contact information: This email address is being protected from spambots. You need JavaScript enabled to view it.
• Further information about the position: A PhD position (fully funded for students world-wide) is available at the lab of Dr P. Kritsiligkou. Please contact them directly for more information on how to apply.

Remember that if there’s an open position in your lab for early career researchers and you would like to advertise it in our newsletter, just write us an email This email address is being protected from spambots. You need JavaScript enabled to view it. containing the following information:

• Kind of position: (PhD student, Postdoc, etc)
• Research topic
• Institute/University
• Deadline
• Contact information
• Further information about the position (if any)

Dear colleagues, 

In today's newsletter, we are excited to announce the final webinar of the season discussing Redox methods and the launch of the call for new ECR fellowships. We will also share with you a summary of November's webinar and of the PhD symposium. At the end of the newsletter, as always, you can also find a collection of upcoming events with important deadlines, some suggestions of interesting redox reads recently published, open call for papers and job opportunities for young redox researchers.

Next Webinar series “Emerging leaders in redox biology”

The final webinar of the year will take place on December 3rd, 2024, at 15:00 CET, focusing on the important topic “Redox methods” with featured speakers James Cobley and Rafael Argüello.

Oxiforms: Redox biology at the proteoform level

James Cobley, PhD
School of Life Sciences, University of Dundee, Dundee, United Kingdom

After studying the redox aspects of sports supplements as an exercise physiology student, James Cobley joined Abertay University (Dundee) to research the biology of reactive oxygen species (ROS) in the nervous system, with a particular focus on synapse pruning. During this time, he visited the lab of Prof. Michael Murphy to learn the art of measuring ROS, particularly mitochondrial superoxide using MitoNeD. Thereafter, James joined the University of the Highlands and Islands (Inverness) to study cysteine redox biology using microplate-based techniques and developed the idea of oxiforms: cysteine redox proteoforms. Presently, James is post-doctoral researcher in the lab of Prof. Angus Lamond at Dundee University. There, James is applying mass spectrometry based proteomics to analyse adipose tissue from identical and non-identical human twins, using the Astral machine. He is also working on methods to measure cysteine redox proteoforms using mass spectrometry.

Decoding complexity: A closer look at stress, metabolism and epigenetic crosstalks through Epic-SCENITH and SNUPR

Rafael Argüello, PhD
Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France

Rafael J. Argüello is tenured research associate at CNRS (Marseille) and the inventor of SCENITHTM, a method for metabolic profiling with single cell resolution. A molecular biologist with a PhD in Human Immunology from Argentina (UBA) and postdoctoral work at CIML and UCSF, his research now focuses on stress, metabolism and epigenetics in immune cells. His awards include the 2021 Diversity-Equity and Inclusion Paper of the Year 2021. He co-founded GammaOmics, a startup developing personalized medicine tools, is active in the non-profit-Expedición Ciencia, and is a co-founding member of the European ImmunoMetabolism Network.

ECR Fellowships - New call open!!

If you are an ECR member of the SFRR-E and under 40 years of age in one of the following situations:

• Postdoc (minimum 3 years after the completion of your PhD).
• Scientist returning to academia after a career break
• Scientist less than 3 years into your first academic position.

You can apply to one of the SFRR-E/OCC ECR Fellowships! These fellowships provide funding up to 10.000€ for a 12-month period supporting research or seed-funding for a new project relevant for the redox field.

If you are interested in applying, please submit your application via the SFRR-E intranet. Deadline: 20th December 2024.

More information as well as the application form are available in the members area of the SFRR-E web: https://intranet.sfrr-europe.org

Good luck to you all!

New ECR subcommittee members - call open until the 29th November!

The ECR subcommittee is looking for new members! Are you interested in joining a vibrant redox community trying to support young researchers in the redox field? We have open spots in the following committees: social media team, newsletter team, webinar team and mentoring program.

If you are less than 40 years old and/or you have defended your PhD thesis less than 10 years ago and you would like to contribute to the redox ECR community, we are looking forward to meeting you!

The call is now open until the 29th November 2024.

You can apply by filling out this form: https://www.surveymonkey.com/r/LPMHD6C or directly reach out to us if you have questions!

Second Edition of the PhD Redox Relay Online Symposium:

On the 19th November six enthusiastic PhD students showcased their research at the 2nd Edition of our PhD Symposium!

Each presenter did an excellent job presenting their PhD projects in just 5 minutes! The symposium covered a diverse range of topics, from aging and sports science to the cutting-edge field of persulfides and chronic diseases. The students presented their data with enthusiasm, shared their ideas with confidence, and tackled even the toughest questions with ease.

It was a real pleasure listening to them and if this is the future of redox biology, we are very excited for the years to come!

Please acknowledge our brave PhD students!

If you missed it, you can find the symposium on the society’s intranet!

November's webinar:

On November's webinar we enjoyed two great talks on the topic “Redox in Photosynthetic organisms” by Sophie Hendrix and Libero Gurrieri.

Glutathione peroxidase-like 8 (GPXL8): A new player in hydrogen peroxide signalling in Arabidopsis thaliana?

Sophie Hendrix, PhD
Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
Department of Biology, University of Antwerp, Antwerp, Belgium

Do you feel the heat? Plant cells depend on an extensive antioxidant defense network to keep reactive oxygen species (ROS) at sub-toxic levels. One member of this network is glutathione peroxidases (GPX). In mammalian cells, GPXs detoxify hydrogen peroxide (H2O2) via the GSH/GR/NADPH redox relay, while plant GPXs, in contrast, use the TRX/NTR/NADPH redox relay, and therefore named GPX-like proteins or GPXLs. Dr. Sophie Hendrix shared with us the potential role of a GPXL in alleviating heat-induced ferroptosis plants. A type of programmed cell death dependent on Iron that is well understood in mammal cells but with limited information in plants. Moreover, Dr. Hendrix proved that this GPXL can work as a new H₂O₂ sensor in vitro and in vivo. Using different variants of this GPXL, they have gained further insight into the importance of each of its conserved cysteines in establishing the protein’s oxidoreductase activity. These new discoveries contribute to elucidating the function of uncharacterized plant GPXLs and open the possibility of generating new redox sensors for H₂O₂.

Redox control of starch degradation interlaces glutathione, thioredoxins and guard cell function

Libero Gurrieri, PhD
Molecular Plant Physiology Lab, Department of Pharmacy and Biotechnology, University of Bologna, Italy

Take a breath! Plants use stomata as pores for gas exchange, letting carbon dioxide (CO2) in for carbon fixation and water out as vapor. Stomata opening and closing are mediated by a pair of guard cells that, in turn, are controlled by multiple factors, including starch degradation. Starch is the carbohydrate reserve that plants build during the day and use during the night when photosynthesis is not possible. Starch degradation leads to ATP production, which activates ion channels that ultimately change the cell water potential, facilitating stomata closure. In this webinar, Dr. Libero Gurrieri presented his work on characterizing BAM1, a chloroplast beta-amylase regulated by redox. BAM1 is inactive upon forming an intramolecular disulfide bond and active when reduced. He proved that mutant lines for chloroplastic glutathione reductase (GR) have more degraded starch, indicating increased amylase activity, and they are currently following the hypothesis that GSH can glutathionylate BAM1, protecting it from redox inactivation. The following research will focus on the connection between the redox-regulated amylase activity and stomata opening, reinforcing the redox-gas exchange link in plant leaves.


More information about the ECR Subcommittee can be found on the SFRR-E website (ECR Committee), while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: This email address is being protected from spambots. You need JavaScript enabled to view it..

Hope to see you online for our next Webinar Series appointment,

The ECR subcommittee

Upcoming events:

22nd SFRRI Biennial Meeting

The New Era of Redox Biology: from Basic Biochemistry to Redox Omics
3 - 6 June 2025
Location: Galway, Ireland
Deadlines:
Travel Grant Applications: 10 January 2025
Abstract Submission: 10 February 2025
Early Bird Registration: 31 March 2025
Further information: https://www.sfrrgalway2025.com

FASEB Science Research Conference. Ferroptosis, Oxidative Stress, and Lipid Metabolism

27 - 31 July 2025
Location: Scottsdale, Arizona
Deadlines:
Abstract Submission: 1 June 2025
Early Registration: 15 June 2025
Housing: 13 July 2025
Further information: https://events.faseb.org/event/11797f9e-df16-42b9-9c47-f1e06713c4fb/summary 

Interesting Redox Papers:

Lang, L., Reinert, P., Diaz, C. & Deponte, M. The dithiol mechanism of class I glutaredoxins promotes specificity for glutathione as a reducing agent. Redox Biol (2024). https://doi.org/10.1016/j.redox.2024.103410

Fiorenza, M., Onslev, J., Henríquez-Olguín., C., et al. Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans. Sci Adv (2024). https://doi.org/10.1126/sciadv.adq4461

Sarah Barakat, Şeyma Çimen, Ş, Miri, SM., et al. Bioenergetic shift and proteomic signature induced by lentiviral-transduction of GFP-based biosensors. Redox Biol (2024). https://doi.org/10.1016/j.redox.2024.103416

Pérez-Chávez, I., Koberstein, J.N., Malo Pueyo, J., et al. Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor. iScience (2024). https://doi.org/10.1016/j.isci.2024.111336

Choudhary, D., Foster, K.R. & Uphoff, S. The master regulator OxyR orchestrates bacterial oxidative stress response genes in space and time. Cell Syst (2024) https://doi.org/10.1016/j.cels.2024.10.003

Ito, J., Nakamura, T., Toyama, T., et al. PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization. Mol Cell (2024). https://doi.org/10.1016/j.molcel.2024.10.028

Ryu, K.W., Fung, T.S., Baker, D.C., et al. Cellular ATP demand creates metabolically distinct subpopulations of mitochondria. Nature (2024). https://doi.org/10.1038/s41586-024-08146-w

Chen, Z., Inague, A., Kaushal, K. et al. PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance. Mol Cell (2024). https://doi.org/10.1016/j.molcel.2024.10.027

Gomes, F., Turano, H., Haddad, L.A. & Netto, L.E.S. Human mitochondrial peroxiredoxin Prdx3 is dually localized in the intermembrane space and matrix subcompartments. Redox Biol (2024) https://doi.org/10.1016/j.redox.2024.103436

Pace, P.E., Fu, L., Hampton, M.B. & Winterbourn, C.C.. Redox proteomic analysis of H2O2 -treated Jurkat cells and effects of bicarbonate and knockout of peroxiredoxins 1 and 2. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.10.314

Insightful Redox Reviews:

Zachary J. Rogers, Z.J., Flood, D. & Taylor, C.T. Oxygen control in cell culture – your cells may not be experiencing what you think! Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.11.036

 Sies, H. SFRRI Inaugural Alberto Boveris Award Lecture Dynamics of Intracellular and Intercellular Redox Communication. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.11.002

Jackson, MJ. Exercise-induced adaptations to homeostasis of reactive oxygen species in skeletal muscle. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.10.270

José Viña, J., Borrás, C. & Mas-Bargues, C. Free radicals in Alzheimer's disease: From pathophysiology to clinical trial results. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.09.051

Duong, L.D., West, J.D. & Morano, K.A. Redox Regulation of Proteostasis. J Biol Chem (2024). https://doi.org/10.1016/j.jbc.2024.107977

Lastest Redox Preprints:

Agostinis, P., Rizzollo, F., Escamilla-Ayala, A., et al. A Bdh2-driven Lysosome to Mitochondria Iron Trafficking Controls Ferroptosis in Melanoma. Research Square (2024). https://doi.org/10.21203/rs.3.rs-5345588/v1 

Call for papers:

Journal: Free Radical Biology and Medicine
Special Issue: Redox medicine: Translation of Basic science to the Clinic
Submission deadline: 1 March 2025
More information: https://www.sciencedirect.com/special-issue/314690/redox-medicine-translation-of-basic-science-to-the-clinic

Redox Job Opportunities:

Postdoc positions

• Kind of position: Postdoc (2 years)
• Research topic: Physiology and Pharmacology
• Institute/University: Karolinska Institute, Stockholm
• Deadline: 31st January 2025
• Contact information: This email address is being protected from spambots. You need JavaScript enabled to view it.
• Further information about the position: We are searching for someone skilled in biochemistry and/or chemical biology. Knowledge in EPR technique is highly appreciated.


• Kind of position: Postdoc (3 years)
• Research topic: Post-translational Modifications and Proliferation
• Institute/University: The Institute of Cancer Research, London ( Dr. Jörg Mansfeld Lab)
• Deadline: 15th December 2024 (Interviews January 2025)
• Contact information: This email address is being protected from spambots. You need JavaScript enabled to view it.
• Further information about the position: we are seeking a highly motivated and ambitious candidate for a Postdoctoral Training Fellow position, with experience in cell cycle research, ubiquitin, or redox biology. A strong cell biology or biochemistry background with an emphasis on the regulation of protein-protein interactions and mechanistic studies in vitro or in cells is highly desirable. Knowledge in DNA replication and/or DNA damage repair is desirable.
• Lab webpage: https://www.mansfeldlab.com
• To apply:
https://jobs.icr.ac.uk/vacancies/1059/postdoctoral-training-fellow--post-translational-modifications-and-cell-proliferation.html

PhD positions

• Kind of position: PhD position (4 years)
• Research topic: Understanding intracellular redox heterogeneity - www.kritsiligkou.com
• Institute/University: The University of Liverpool
• Deadline: 31 December 2024
• Contact information: This email address is being protected from spambots. You need JavaScript enabled to view it.
• Further information about the position: A PhD position (fully funded for UK students only) is available at the lab of Dr P. Kritsiligkou. Please contact them directly for more information on how to apply.

Remember that if there’s an open position in your lab for early career researchers and you would like to advertise it in our newsletter, just write us an email (This email address is being protected from spambots. You need JavaScript enabled to view it.) containing the following information:

• Kind of position: (PhD student, Postdoc, etc)
• Research topic
• Institute/University
• Deadline
• Contact information
• Further information about the position (if any)

This Tuesday 19th November at 15:00 CET six talented postgraduate researchers will present their work at the 2nd PhD Mini Symposium!

1. Abril Gorgori - Harmol as a nutritionalstrategy to improve aged mitochondria

2. Javier Huete Acevedo - Extracellular vesicles from adipose derived stem cells from young mice improve cognition in old mice

3. Marta Arnal - Differential content of small extracellular vesicles obtained from plasma of young, old and centenarian humans

4. Roberto Andrés Meneses Valdés - Spatiotemporal manipulation of hydrogen peroxide as a novel model for skeletalmuscle wasting in mouse muscle

5. Danny Schilling - The emerging role of protein persulfides in biology

6. Martina Ciarnelli - Study of the immunometabolic alterations in the monocyte/macrophage system in chronic diseases

Join us to celebrate the work of the new generation of redox scientists!

https://us06web.zoom.us/j/86469731540?pwd=cQW0yK5sNCPXO5sSOcaoBHaZPy2Tu8.1 

Passcode: 433382

More information about the ECR Subcommittee can be found on the SFRR-E website ECR Committee, while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: This email address is being protected from spambots. You need JavaScript enabled to view it..

Hope to see you online, 
The ECR subcommittee