NEWS

Dear colleagues, dear SFRR-E members, dear friends,

It has been an honour and a pleasure to serve SFRR-Europe during these last twelve years. I have done my best to contribute to the growth of our Society.

We are delighted to see the significant increase in our membership from 2013, when we started with the sponsorship from Elsevier with only 150 members, to the current membership with almost 600 members. This success has been achieved by a great team’s work involving the SFRR-E Executive Committee, the Council, and more recently the ECR Committee. I would like to give special thanks to our previous Presidents during all this time, Daniela Caporossi, Michael Davies, Giovanni Mann, Josiane Cillard, and Nesrin Kartal-Özer for their excellent work leading the Society as well as to Clare Hawkins as General Secretary, Brigitte Winkloher-Roob and Niki Chondrogianni as Meeting Officers, and Aphrodite Vasilaki and Corinne Spickett as Treasurers for their great work.

The SFRR-E ECR Committee was created in 2022 with Carmen Veith elected as the first Chair serving until June 2024, when Pari Kritsiligkou became Chair of this Committee. All members of this committee, especially Carmen and Pari, have contributed so much to the increase in our membership and to make our society vibrant regularly running very interesting webinars by outstanding young researchers in the redox biology field, mentoring programs as well as disseminating all SFRR-E activities through the social media. Their enormous efforts for the society are very much appreciated.

Many thanks also to those who have organized our excellent Annual Meetings during all these 12 years with such outstanding efforts, starting with Emrah Eroglu and Nesrin Kartal-Özer for Istanbul 2024, Florian Gruber for Vienna 2023; Daniela Caporossi, Claire Remacle, Rémi Willamme, and Frank Breusegem for the joint SFRR-E/POG Meeting Ghent 2022, and Joel Pincemail for his efforts trying to hold that joint meeting in Liège; Bato Korac for Belgrade 2021; Giuseppe Valacchi for Ferrara 2019; João Laranjinha for SFRR-I Lisbon 2018; Tilman Grune for Berlin 2017; Zolt Radak for Budapest 2016; Jan Frank for Stuttgart 2015; Bertrand Friguet and Josiane Cillard for Paris 2014; and Stathis Gonos for Athens 2013. In addition, the extensive dedication by Brigitte Winkloher-Roob to our Annual Meetings during the last years is much appreciated. We cannot forget either the outstanding SFRR-I 2012 Meeting organized by Giovanni Mann and Malcolm Jackson in London. All these meetings leave me with special memories that will remain forever.

I would like also to give many thanks to Niki Chondrogianni, Aphrodite Vasilaki, Daniela Caporossi, Tilman Grune, Lars-Oliver Klotz, and Corinne Spickett for their great contribution to the training of young investigators in our exciting field in the Spetses Summer School.


The SFRR-E website was created in 2012 by our web manager Rodrigo Ribes, who has maintained and improved it during all these years, becoming a few years ago Assistant Secretary of the society and playing a fundamental role handling our membership and supporting all webinars, so I also would like to give special thanks to Rodrigo.

We appreciate the long-term sponsorship from Elsevier and the very valuable help from Anthony Newman, Manon Burger, Lydia Briggs, and Rafael Teixeira, which has underpinned for all our Annual Meetings and our outreach activities. The funding provided by the Oxygen Club of California with the generous support of Enrique Cadenas is also much appreciated and has contributed very importantly to the fellowships to young researchers and to maintain a high quality of our annual meetings. A special memory to our dear friends Lester Packer, John Maguire, and Pierre Cillard.

Next year SFRR-E will host the SFRR-International Biennial Meeting 2025, which is being organized by Kasia Whysall and will be held in Galway, Ireland, on the 3^rd-6^th June with the theme “The New Era of Redox Biology: from Basic Biochemistry to Redox Omics”. Please remember the deadlines for SFRR-E and SFRR-I/OCC travel awards for students and postdocs to attend this meeting -17^th January 2025-, for abstract submission -10^th February 2025-, and for early bird registration -20^th March 2025-.

I am certain that our Society will be in very good hands with Giuseppe Valacchi as President from January 2025 and Clare Hawkins continuing as General Secretary together with the excellent team composed by Irundika Dias as new Treasurer, Brigitte Winklhofer-Roob and Niki Chondrogianni as Meeting Officers, Giovanni Mann , Michael Davies, and Enrique Cadenas as Scientific Advisors, and the new SFRR-E Council. In addition, the ECR Committee and the new generations to come will ensure a long life for our society.

Finally, I do hope that the new year will bring the end of the wars in Ukraine and Middle East as well as the recovery of the many villages of my region of Valencia that were recently devastated by the severe floods.
It has been a pleasure to collaborate with most of you during all these years, and I do look forward to seeing you again in Galway in June.

With my best wishes for all of you for the special season holidays, and for a very happy New Year 2025!

All the best,
Juan Sastre
Outgoing SFRR-E President

I am writing on behalf of the SFRRI Executive to wish you the very best for the seasons holiday.

I am delighted to welcome Prof. Roland Stocker as the new SFRRI President, Prof. Hozumi Motahashi as the new SFRRI President-Elect and Prof. Corinne Spickett as the new SFRRI Treasurer. Roland, Hozumi and Corinne will be taking up their positions on 1 January 2025, and Patricia Oteiza will continue to serve as General Secretary. I will serve on the SFRRI Executive as Past-President for the next two years.

On behalf of Patricia Oteiza, Roland Stocker and Jose Vina and all regional SFRR Societies, I would like express our appreciation to Prof. Lin Mantell, who as SFRRI Treasurer underpinned the management of our Society’s finances and outreach support. Lin Mantell was instrumental in liaising effectively with regional SFRR Societies and in particular in leading the SFRRI ‘Women in Science’ initiative launched at the 19^th SFRRI Biennial Meeting in Lisboa, Portugal in 2018. We thank Lin for her continued commitment to SFRRI and involvement in strengthening the links between regional SFRR Societies and our redox community.

SFFR-Europe is hosting the 22^nd SFRRI Biennial Meeting in Galway, Ireland from 3-6 June 2025 https://www.sfrrgalway2025.com  and, as Chair of this meeting, Kasia Whysall is liaising closely with the Executives of SFRR-Europe and SFRRI. An international scientific committee selected 12 symposia from a total 25 submitted proposals and 9 keynote lectures:

• SFRRI Trevor Slater Awards (Prof. Michael Davies and Prof Giovanni Mann)
• SFRRI Lester Packer Award (Prof. Giuseppe Poli)
• SFRRI Alberto Boveris Award (Prof. Enrique Cadenas)
• SFRRI Kelvin & Joanna Davies Rising Star Award (Dr. Carlos Henriquez Olguín)
• SFRR-E Annual Award (Prof. Daniela Caporossi)
• SFRR-E Basic Science Award (Prof. Juan Sastre)
• SFRR-E Leopold Flohe Redox Pioneer Award (Dr. Aphrodite Vasilaki)
• SFRR-E Catherine Pasquier Award (Dr. Paraskevi Kritsiligkou)

Ireland is a country renowned for its natural beauty and Galway is known as Ireland’s cultural heart. The meeting will be held in the University of Galway, which is conveniently located a 5-min walk of Galway city centre and 10-min walk to campus accommodation. In addition to university accommodation, there are international hotels and many fine guesthouses and apartment rentals within easy walking distance of the conference venue. Galway is served by an extensive public transport network linking Dublin, Shannon and Knock airports.

We look forward to welcoming you at the 22^nd SFRRI Biennial Meeting in Galway, Ireland in June 2025! Early career researchers who are members of a regional SFRR Society are eligible to apply for SFRRI and Oxygen Club of Calfornia Travel Awards to partially support travel/subsistence to present their research as oral or poster communications.

I welcome regional SFRR Societies emailing me further information from their Society, which can be uploaded on the SFRRI website.

It has been an honour to serve as SFRRI President for the past years, and I will continue to actively support and strengthen SFRRI interactions with regional SFRR Societies and the wider redox community.

With my best wishes for the seasons holidays,
Giovanni E. Mann
President SFRR-International

Dear colleagues,

We remind you that the deadline for the Call for applications for the SFRR-E / OCC Early Career Researcher (ECR) Fellowships is 20th December, 2024.

The Fellowships are intended to provide ECRs support of up to 10,000€ for research or seed-funding for a new project, which should be relevant to the field of redox research and completed within a 12-month period.

The Fellowships cannot be used to cover salary costs and should not overlap with existing funding. Applicants must clearly outline how the Fellowship will assist them in achieving their future career goals.

Information about eligibility and the application process is outlined in the attached guidelines. Applicants must be current financial members of SFRR-E and can download the application form by logging in to the members area of the SFRR-E website (https://intranet.sfrr-europe.org/).

To login into the member area of the website: click on “Member login & renewal” which is under the “Membership” drop down menu. Choose the “SFRR-E / OCC ECR Fellowship” option in the blue menu on the left hand side. This page will also allow you to join the Society or renew your membership if applicable.

Applications should be submitted using the form provided, together with the required attachments, as a single PDF file through the SFRR-E member area of the website before the deadline of 20th December, 2024.

Each application will be assessed by 3 independent peer reviewers identified by SFRR-E.

Best wishes,
Clare Hawkins
General Secretary, SFRR-Europe

Dear colleagues,

We are pleased to announce that additional Travel Awards will be available for students and postdocs to attend the 2025 biennial meeting of SFRR-I that will be organised by SFRR-E and held in Galway, Ireland, from 3 - 6 June 2025.

Society for Free Radical Research International (SFRR-I) / Oxygen Club of California (OCC) Travel Awards

SFRR-I / OCC will provide Travel Awards of up to 800 Euros each for PhD students or postdoc members of a SFRR Regional Society, who are less than 5 years post-PhD (excluding career disruption) and not in permanent academic positions, who require transoceanic or long-distance travel to attend the forthcoming 22nd SFRR-I Biennial Meeting.

Please note that SFRR-Europe is also offering travel awards and any SFRR-Europe applicant cannot apply for both SFRRI/OCC and SFRR-E travel awards.

The number of travel awards for PhD, post-doc, and international junior researchers will be decided after the evaluation process taking into account the scientific quality of the proposals and geographic distribution.

The applications should be submitted online through the SFRR-E intranet https://intranet.sfrr-europe.org as a single PDF file containing a CV (max. 2 pages), which includes the date of PhD award, a supporting letter written by the applicant, outlining your interest and motivation for attending the conference, and an abstract for the communication to be presented during the conference.

As registered user of the SFRR-E intranet you will have access to submit your application when you login into the website https://intranet.sfrr-europe.org and select the option “Call for SFRR-I/OCC Travel Awards for SFRR-I Galway ” in the menu on the left.

The deadline to receive submissions is 17th January 2025. The decision about awardees will be announced before the early-bird registration deadline and the corresponding funds will be transferred to the awardees soon after this announcement.

PLEASE NOTE: applicants MUST submit their abstracts online through the conference website before 10th February 2025, which is the deadline for abstract submission, and provide evidence of registration, to receive the travel funds.

Conference website: https://www.sfrrgalway2025.com

Please contact info@sfrr-europe.org should you need further information.

Dear colleagues,

We are pleased to announce that travel awards will be available for students and postdocs to attend the 2025 biennial meeting of SFRR-I that will be organised by SFRR-E and held in Galway, Ireland, from 3 - 6 June 2025.

Society for Free Radical Research Europe (SFRR-E) Travel Awards

SFRR-E will provide Travel Awards of 400 Euros each for PhD students members of SFRR-E and postdoc members of SFRR-E, who are less than 5 years post-PhD (excluding career disruption) and not in permanent academic positions.

For the SFRR-E awards, previous SFRR-E Travel Grant awardees and SFRR-E Young Investigator Award recipients, who have been supported to attend the SFRR-E annual conference previously, are not eligible to apply for a SFRR-E travel award. You are eligible to apply for a SFRRI/OCC Travel Award, but eligible SFRR-E members cannot apply for both SFRRI/OCC and SFRR-E awards.

The number of travel awards for European PhD students, postdocs, and junior researchers will be decided after the evaluation process taking into account the scientific quality of the proposals.

The applications should be submitted online through the SFRR-E intranet https://intranet.sfrr-europe.org as a single PDF file containing a CV (max. 2 pages), which includes the date of PhD award, a supporting letter written by the applicant, outlining your interest and motivation for attending the conference, and an abstract for the communication to be presented during the conference.

As registered user of the SFRR-E intranet you will have access to submit your application when you login into the website https://intranet.sfrr-europe.org and select the option “Travel Awards for SFRR-E” in the menu on the left.

The deadline to receive submissions is 17th January 2025. The decision about awardees will be announced before the early-bird registration deadline and the corresponding funds will be transferred to the awardees soon after this announcement.

PLEASE NOTE: applicants MUST submit their abstracts online through the conference website before 10th February 2025, which is the deadline for abstract submission, and provide evidence of registration, to receive the travel funds.

Conference website: https://www.sfrrgalway2025.com

Please contact info@sfrr-europe.org should you need further information.

To apply for a travel grant, log in to the SFRR-E intranet at https://intranet.sfrr-europe.org and select the option in the left-hand menu: Call for SFRR-E Travel Awards for SFRR-I Galway 2025

Dear colleagues, 

In today's newsletter, we are excited to announce the final webinar of the season discussing Redox methods and the launch of the call for new ECR fellowships. We will also share with you a summary of November's webinar and of the PhD symposium. At the end of the newsletter, as always, you can also find a collection of upcoming events with important deadlines, some suggestions of interesting redox reads recently published, open call for papers and job opportunities for young redox researchers.

Next Webinar series “Emerging leaders in redox biology”

The final webinar of the year will take place on December 3rd, 2024, at 15:00 CET, focusing on the important topic “Redox methods” with featured speakers James Cobley and Rafael Argüello.

Oxiforms: Redox biology at the proteoform level

James Cobley, PhD
School of Life Sciences, University of Dundee, Dundee, United Kingdom

After studying the redox aspects of sports supplements as an exercise physiology student, James Cobley joined Abertay University (Dundee) to research the biology of reactive oxygen species (ROS) in the nervous system, with a particular focus on synapse pruning. During this time, he visited the lab of Prof. Michael Murphy to learn the art of measuring ROS, particularly mitochondrial superoxide using MitoNeD. Thereafter, James joined the University of the Highlands and Islands (Inverness) to study cysteine redox biology using microplate-based techniques and developed the idea of oxiforms: cysteine redox proteoforms. Presently, James is post-doctoral researcher in the lab of Prof. Angus Lamond at Dundee University. There, James is applying mass spectrometry based proteomics to analyse adipose tissue from identical and non-identical human twins, using the Astral machine. He is also working on methods to measure cysteine redox proteoforms using mass spectrometry.

Decoding complexity: A closer look at stress, metabolism and epigenetic crosstalks through Epic-SCENITH and SNUPR

Rafael Argüello, PhD
Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France

Rafael J. Argüello is tenured research associate at CNRS (Marseille) and the inventor of SCENITHTM, a method for metabolic profiling with single cell resolution. A molecular biologist with a PhD in Human Immunology from Argentina (UBA) and postdoctoral work at CIML and UCSF, his research now focuses on stress, metabolism and epigenetics in immune cells. His awards include the 2021 Diversity-Equity and Inclusion Paper of the Year 2021. He co-founded GammaOmics, a startup developing personalized medicine tools, is active in the non-profit-Expedición Ciencia, and is a co-founding member of the European ImmunoMetabolism Network.

ECR Fellowships - New call open!!

If you are an ECR member of the SFRR-E and under 40 years of age in one of the following situations:

• Postdoc (minimum 3 years after the completion of your PhD).
• Scientist returning to academia after a career break
• Scientist less than 3 years into your first academic position.

You can apply to one of the SFRR-E/OCC ECR Fellowships! These fellowships provide funding up to 10.000€ for a 12-month period supporting research or seed-funding for a new project relevant for the redox field.

If you are interested in applying, please submit your application via the SFRR-E intranet. Deadline: 20th December 2024.

More information as well as the application form are available in the members area of the SFRR-E web: https://intranet.sfrr-europe.org

Good luck to you all!

New ECR subcommittee members - call open until the 29th November!

The ECR subcommittee is looking for new members! Are you interested in joining a vibrant redox community trying to support young researchers in the redox field? We have open spots in the following committees: social media team, newsletter team, webinar team and mentoring program.

If you are less than 40 years old and/or you have defended your PhD thesis less than 10 years ago and you would like to contribute to the redox ECR community, we are looking forward to meeting you!

The call is now open until the 29th November 2024.

You can apply by filling out this form: https://www.surveymonkey.com/r/LPMHD6C or directly reach out to us if you have questions!

Second Edition of the PhD Redox Relay Online Symposium:

On the 19th November six enthusiastic PhD students showcased their research at the 2nd Edition of our PhD Symposium!

Each presenter did an excellent job presenting their PhD projects in just 5 minutes! The symposium covered a diverse range of topics, from aging and sports science to the cutting-edge field of persulfides and chronic diseases. The students presented their data with enthusiasm, shared their ideas with confidence, and tackled even the toughest questions with ease.

It was a real pleasure listening to them and if this is the future of redox biology, we are very excited for the years to come!

Please acknowledge our brave PhD students!

If you missed it, you can find the symposium on the society’s intranet!

November's webinar:

On November's webinar we enjoyed two great talks on the topic “Redox in Photosynthetic organisms” by Sophie Hendrix and Libero Gurrieri.

Glutathione peroxidase-like 8 (GPXL8): A new player in hydrogen peroxide signalling in Arabidopsis thaliana?

Sophie Hendrix, PhD
Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
Department of Biology, University of Antwerp, Antwerp, Belgium

Do you feel the heat? Plant cells depend on an extensive antioxidant defense network to keep reactive oxygen species (ROS) at sub-toxic levels. One member of this network is glutathione peroxidases (GPX). In mammalian cells, GPXs detoxify hydrogen peroxide (H2O2) via the GSH/GR/NADPH redox relay, while plant GPXs, in contrast, use the TRX/NTR/NADPH redox relay, and therefore named GPX-like proteins or GPXLs. Dr. Sophie Hendrix shared with us the potential role of a GPXL in alleviating heat-induced ferroptosis plants. A type of programmed cell death dependent on Iron that is well understood in mammal cells but with limited information in plants. Moreover, Dr. Hendrix proved that this GPXL can work as a new H₂O₂ sensor in vitro and in vivo. Using different variants of this GPXL, they have gained further insight into the importance of each of its conserved cysteines in establishing the protein’s oxidoreductase activity. These new discoveries contribute to elucidating the function of uncharacterized plant GPXLs and open the possibility of generating new redox sensors for H₂O₂.

Redox control of starch degradation interlaces glutathione, thioredoxins and guard cell function

Libero Gurrieri, PhD
Molecular Plant Physiology Lab, Department of Pharmacy and Biotechnology, University of Bologna, Italy

Take a breath! Plants use stomata as pores for gas exchange, letting carbon dioxide (CO2) in for carbon fixation and water out as vapor. Stomata opening and closing are mediated by a pair of guard cells that, in turn, are controlled by multiple factors, including starch degradation. Starch is the carbohydrate reserve that plants build during the day and use during the night when photosynthesis is not possible. Starch degradation leads to ATP production, which activates ion channels that ultimately change the cell water potential, facilitating stomata closure. In this webinar, Dr. Libero Gurrieri presented his work on characterizing BAM1, a chloroplast beta-amylase regulated by redox. BAM1 is inactive upon forming an intramolecular disulfide bond and active when reduced. He proved that mutant lines for chloroplastic glutathione reductase (GR) have more degraded starch, indicating increased amylase activity, and they are currently following the hypothesis that GSH can glutathionylate BAM1, protecting it from redox inactivation. The following research will focus on the connection between the redox-regulated amylase activity and stomata opening, reinforcing the redox-gas exchange link in plant leaves.


More information about the ECR Subcommittee can be found on the SFRR-E website (ECR Committee), while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: ecr@sfrr-europe.org.

Hope to see you online for our next Webinar Series appointment,

The ECR subcommittee

Upcoming events:

22nd SFRRI Biennial Meeting

The New Era of Redox Biology: from Basic Biochemistry to Redox Omics
3 - 6 June 2025
Location: Galway, Ireland
Deadlines:
Travel Grant Applications: 10 January 2025
Abstract Submission: 10 February 2025
Early Bird Registration: 31 March 2025
Further information: https://www.sfrrgalway2025.com

FASEB Science Research Conference. Ferroptosis, Oxidative Stress, and Lipid Metabolism

27 - 31 July 2025
Location: Scottsdale, Arizona
Deadlines:
Abstract Submission: 1 June 2025
Early Registration: 15 June 2025
Housing: 13 July 2025
Further information: https://events.faseb.org/event/11797f9e-df16-42b9-9c47-f1e06713c4fb/summary 

Interesting Redox Papers:

Lang, L., Reinert, P., Diaz, C. & Deponte, M. The dithiol mechanism of class I glutaredoxins promotes specificity for glutathione as a reducing agent. Redox Biol (2024). https://doi.org/10.1016/j.redox.2024.103410

Fiorenza, M., Onslev, J., Henríquez-Olguín., C., et al. Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans. Sci Adv (2024). https://doi.org/10.1126/sciadv.adq4461

Sarah Barakat, Şeyma Çimen, Ş, Miri, SM., et al. Bioenergetic shift and proteomic signature induced by lentiviral-transduction of GFP-based biosensors. Redox Biol (2024). https://doi.org/10.1016/j.redox.2024.103416

Pérez-Chávez, I., Koberstein, J.N., Malo Pueyo, J., et al. Tracking fructose 1,6-bisphosphate dynamics in liver cancer cells using a fluorescent biosensor. iScience (2024). https://doi.org/10.1016/j.isci.2024.111336

Choudhary, D., Foster, K.R. & Uphoff, S. The master regulator OxyR orchestrates bacterial oxidative stress response genes in space and time. Cell Syst (2024) https://doi.org/10.1016/j.cels.2024.10.003

Ito, J., Nakamura, T., Toyama, T., et al. PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization. Mol Cell (2024). https://doi.org/10.1016/j.molcel.2024.10.028

Ryu, K.W., Fung, T.S., Baker, D.C., et al. Cellular ATP demand creates metabolically distinct subpopulations of mitochondria. Nature (2024). https://doi.org/10.1038/s41586-024-08146-w

Chen, Z., Inague, A., Kaushal, K. et al. PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance. Mol Cell (2024). https://doi.org/10.1016/j.molcel.2024.10.027

Gomes, F., Turano, H., Haddad, L.A. & Netto, L.E.S. Human mitochondrial peroxiredoxin Prdx3 is dually localized in the intermembrane space and matrix subcompartments. Redox Biol (2024) https://doi.org/10.1016/j.redox.2024.103436

Pace, P.E., Fu, L., Hampton, M.B. & Winterbourn, C.C.. Redox proteomic analysis of H2O2 -treated Jurkat cells and effects of bicarbonate and knockout of peroxiredoxins 1 and 2. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.10.314

Insightful Redox Reviews:

Zachary J. Rogers, Z.J., Flood, D. & Taylor, C.T. Oxygen control in cell culture – your cells may not be experiencing what you think! Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.11.036

 Sies, H. SFRRI Inaugural Alberto Boveris Award Lecture Dynamics of Intracellular and Intercellular Redox Communication. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.11.002

Jackson, MJ. Exercise-induced adaptations to homeostasis of reactive oxygen species in skeletal muscle. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.10.270

José Viña, J., Borrás, C. & Mas-Bargues, C. Free radicals in Alzheimer's disease: From pathophysiology to clinical trial results. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.09.051

Duong, L.D., West, J.D. & Morano, K.A. Redox Regulation of Proteostasis. J Biol Chem (2024). https://doi.org/10.1016/j.jbc.2024.107977

Lastest Redox Preprints:

Agostinis, P., Rizzollo, F., Escamilla-Ayala, A., et al. A Bdh2-driven Lysosome to Mitochondria Iron Trafficking Controls Ferroptosis in Melanoma. Research Square (2024). https://doi.org/10.21203/rs.3.rs-5345588/v1 

Call for papers:

Journal: Free Radical Biology and Medicine
Special Issue: Redox medicine: Translation of Basic science to the Clinic
Submission deadline: 1 March 2025
More information: https://www.sciencedirect.com/special-issue/314690/redox-medicine-translation-of-basic-science-to-the-clinic

Redox Job Opportunities:

Postdoc positions

• Kind of position: Postdoc (2 years)
• Research topic: Physiology and Pharmacology
• Institute/University: Karolinska Institute, Stockholm
• Deadline: 31st January 2025
• Contact information: Jon.lundberg@ki.se
• Further information about the position: We are searching for someone skilled in biochemistry and/or chemical biology. Knowledge in EPR technique is highly appreciated.


• Kind of position: Postdoc (3 years)
• Research topic: Post-translational Modifications and Proliferation
• Institute/University: The Institute of Cancer Research, London ( Dr. Jörg Mansfeld Lab)
• Deadline: 15th December 2024 (Interviews January 2025)
• Contact information: jorg.mansfeld@icr.ac.uk
• Further information about the position: we are seeking a highly motivated and ambitious candidate for a Postdoctoral Training Fellow position, with experience in cell cycle research, ubiquitin, or redox biology. A strong cell biology or biochemistry background with an emphasis on the regulation of protein-protein interactions and mechanistic studies in vitro or in cells is highly desirable. Knowledge in DNA replication and/or DNA damage repair is desirable.
• Lab webpage: https://www.mansfeldlab.com
• To apply:
https://jobs.icr.ac.uk/vacancies/1059/postdoctoral-training-fellow--post-translational-modifications-and-cell-proliferation.html

PhD positions

• Kind of position: PhD position (4 years)
• Research topic: Understanding intracellular redox heterogeneity - www.kritsiligkou.com
• Institute/University: The University of Liverpool
• Deadline: 31 December 2024
• Contact information: pari@liverpool.ac.uk
• Further information about the position: A PhD position (fully funded for UK students only) is available at the lab of Dr P. Kritsiligkou. Please contact them directly for more information on how to apply.

Remember that if there’s an open position in your lab for early career researchers and you would like to advertise it in our newsletter, just write us an email (ecr@sfrr-europe.org) containing the following information:

• Kind of position: (PhD student, Postdoc, etc)
• Research topic
• Institute/University
• Deadline
• Contact information
• Further information about the position (if any)

This Tuesday 19th November at 15:00 CET six talented postgraduate researchers will present their work at the 2nd PhD Mini Symposium!

1. Abril Gorgori - Harmol as a nutritionalstrategy to improve aged mitochondria

2. Javier Huete Acevedo - Extracellular vesicles from adipose derived stem cells from young mice improve cognition in old mice

3. Marta Arnal - Differential content of small extracellular vesicles obtained from plasma of young, old and centenarian humans

4. Roberto Andrés Meneses Valdés - Spatiotemporal manipulation of hydrogen peroxide as a novel model for skeletalmuscle wasting in mouse muscle

5. Danny Schilling - The emerging role of protein persulfides in biology

6. Martina Ciarnelli - Study of the immunometabolic alterations in the monocyte/macrophage system in chronic diseases

Join us to celebrate the work of the new generation of redox scientists!

https://us06web.zoom.us/j/86469731540?pwd=cQW0yK5sNCPXO5sSOcaoBHaZPy2Tu8.1 

Passcode: 433382

More information about the ECR Subcommittee can be found on the SFRR-E website ECR Committee, while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: ecr@sfrr-europe.org.

Hope to see you online, 
The ECR subcommittee

Dear colleagues,

In today's newsletter, we will announce November's webinar, the new edition of our PhD symposium and the opening of the call for new ECR subcommittee members. We will also share with you a summary of October’s webinar and the winners of the YIA of the Spetses Redox Summer School. At the end of the newsletter, as always, you can also find a collection of upcoming events with important deadlines, some suggestions of interesting redox reads recently published, open call for papers and job opportunities for young redox researchers.

Next Webinar series “Emerging leaders in redox biology”

Our next webinar will be on 5th November 2024 at 15:00 CET on the topic “Redox in Photosynthetic organisms” featuring Sophie Hendrix and Libero Gurrieri.


Glutathione peroxidase-like 8 (GPXL8): A new player in hydrogen peroxide signalling in Arabidopsis thaliana?

Sophie Hendrix, PhD

Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
Department of Biology, University of Antwerp, Antwerp, Belgium

In 2019, Sophie Hendrix obtained her PhD in Biology from Hasselt University (Belgium) under the supervision of Prof. Ann Cuypers. Her doctoral research focused on plant responses to cadmium stress with a particular emphasis on cell cycle regulation and the DNA damage response. Following her PhD, she was awarded an EMBO short-term fellowship to work in the lab of Prof. Andreas Meyer at the University of Bonn (Germany), where she gained experience with genetically-encoded biosensors to study redox dynamics in cadmium-exposed plants. In 2020, she obtained an Alexander von Humboldt postdoctoral fellowship to continue her research at the University of Bonn. During her postdoc, she studied molecular plant responses to heat stress and investigated the involvement of plant glutathione peroxidase-like proteins in redox signalling. She then moved back to Hasselt University, where she continued her postdoctoral work with an SFRR-E Early Career Researcher fellowship. In 2023, she was appointed as an assistant professor at the Centre for Environmental Sciences of Hasselt University. Her current work focuses on dissecting molecular plant responses to combined stress conditions, using Arabidopsis as a model system. Furthermore, she aims to further elucidate the functions of plant glutathione peroxidase-like proteins in plant stress responses.

Redox control of starch degradation interlaces glutathione, thioredoxins and guard cell function

Libero Gurrieri, PhD

Molecular Plant Physiology Lab, Department of Pharmacy and Biotechnology, University of Bologna, Italy

Libero obtained his PhD in Molecular and Cellular Biology at the University of Bologna in 2019. He is currently a junior researcher at the Department of Pharmacy and Biotechnology (University of Bologna, Italy) in the Molecular Plant Physiology Lab, where he held two postdoctoral positions, while he was lecturer at the University of Ferrara (Italy). Libero is investigating the role of post-translational redox modifications on plant enzymes involved in primary carbon metabolism. To gain insight into the basis of redox regulation, his comprehensive approach goes from the protein to the atom, thanks to many collaborations with structural scientists, then validating in plants the in vitro results. He started focusing on how thiol switches control the Calvin-Benson cycle, and recently he is exploring how glutathione-based modifications can modulate starch metabolism. Starch is a primary source of carbon in plants and plays an increasingly important role in gas exchange, providing carbon skeletons and energy to open stomata pores on the leaf surface.

Second Edition of the PhD Redox Relay Online Symposium - SAVE THE DATE! 19th November 2024 at 15:00 CET

It’s our pleasure to present to you the second edition of our PhD Symposium!

For this edition six enthusiastic PhD students will present their work:

1. Roberto Meneses-Valdés, University of Copenhagen
2. Marta Arnal, University of Valencia
3. Martina Ciarnelli, University of Foggia
4. Abril Gorgori, University of Valencia
5. Javier Huete, University of Valencia
6. Danny Schilling, German Cancer Research Center

The PhD symposium will take place online on the 19th November 2024 at 15:00 CET. Please mark that in your calendars!

A detailed newsletter with all the PhD symposium and speakers information will follow, stay tuned!

New ECR subcommittee members - call now open!

If you are less than 40 years old and/or you have discussed your PhD thesis less than 10 years ago and you would like to contribute to the redox ECR community, we have great news for you! We are looking for new members for our ECR subcommittee!

The call is now open until the 29th November 2024.

You can apply by filling out this form: https://www.surveymonkey.com/r/LPMHD6C 

 
October’s webinar:

On October’s webinar we enjoyed an insightful talk on the topic “Peer review process” by Mike Davies:

Insights into the peer review and publication of scientific papers

Mike Davies, Professor

Department of Biomedical Sciences, University of Copenhagen, Denmark

In October’s webinar, Prof. Michael Davies shared with us his editorial long-lasting trajectory and leading role in the main journals in the field of Redox Biology. In particular, he gave highly valuable insights on the peer review process, the independent evaluation of research papers by experts in the field before publishing. We all, as scientists, will be involved in this process as authors or as evaluators! Some of the main editors´ tasks include the assessment of the suitability of a manuscript for the journal, the identification of potential reviewers and the decision-making on manuscript consideration, while some reviewers’ commitments are to prove fair and timely commentaries on new potential manuscripts within their area of expertise. Of note, Prof. Davies valued the importance of this process to get an advanced version of research work as well as acknowledged and encouraged all scientists to get involved in this system, including early career researchers.

Spetses Redox Summer School 2024 - Young Investigator Awards

We would like to highlight the three young researchers that got a SFRR-E Young Investigator Award for their great presentations at the Spetses Redox Summer School 2024: Anne Sophie Scheller (Germany), Felix Schmidt (Germany) and Karoline Scholzen (Sweden). Congratulations to all the awardees!!

More information about the ECR Subcommittee can be found on the SFRR-E website (ECR Committee), while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: ecr@sfrr-europe.org.

Hope to see you online for our next Webinar Series appointment,

The ECR subcommittee

Upcoming events:

SfRBM 2024 Conference

• 31st Annual Conference
• 20 - 23 November 2024
• Location: Savannah, Georgia, USA
• Deadlines:
  • Abstract and Awards Deadline: already closed
  • Early Registration Deadline: 15 October 2024
• Further information: https://sfrbm.org/meetings/sfrbm-2024/ 

22nd SFRRI Biennial Meeting

• The New Era of Redox Biology: from Basic Biochemistry to Redox Omics
• 3 - 6 June 2025
• Location: Galway, Ireland
• Deadlines:
  • Travel Grant Applications: 10 January 2025
  • Abstract Submission: 10 February 2025
  • Early Bird Registration: 31 March 2025
• Further information: https://www.sfrrgalway2025.com 

Interesting Redox Papers:

Keeney, M.T., Rocha, E.M., Hoffman, E.K., et al. LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson’s disease. Sci Transl Med (2024). https://doi.org/10.1126/scitranslmed.adl3438 

Zheng, H., Chen, H., Cai, Y., et al. Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small cell lung cancer. Mol Cell (2024). https://doi.org/10.1016/j.molcel.2024.08.035 

Katopodi, V., Marino, A., Pateraki, N., et al. The long non-coding RNA ROSALIND protects the mitochondrial translational machinery from oxidative damage. Cell Death Differ (2024). https://doi.org/10.1038/s41418-024-01377-4 

Wang, S., Liu, M., Hu, D., et al. Control of DNA demethylation by superoxide anion in plant stem cells. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01737-8 

Liang, F., Zandkarimi, F., Lee, J., et al. OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response. Mol Cell (2024). https://doi.org/10.1016/j.molcel.2024.07.020 

Ersoy, U., Altinpinar, A.E., Kanakis, I., et al. Lifelong dietary protein restriction induces denervation and skeletal muscle atrophy in mice. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.09.005 

Qiao, Z., Nguyen, L.C., Yang, D., et al. Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01716-z

Bian, Y., Shan, G., Guoshu, B. Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis. Redox Biol (2024). https://doi.org/10.1016/j.redox.2024.103361 

Insightful Redox Reviews:

Decker, S.T. & Funai, K. Mitochondrial membrane lipids in the regulation of bioenergetic flux. Cell Metab (2024). https://doi.org/10.1016/j.cmet.2024.07.024 

Donato, L., Mordà, D., Scimone, C., et al. From powerhouse to regulator: The role of mitoepigenetics in mitochondrion-related cellular functions and human diseases. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.03.025 

Meneses-Valdés, R., Gallero, S., Henríquez-Olguín, C. & Jensen, T.E. Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.07.035 

Vilas-Boas, E.A. & Kowaltowski, A.J. Mitochondrial redox state, bioenergetics, and calcium transport in caloric restriction: A metabolic nexus. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.04.234 

Margaritelis, N.V., Cobley, J.N., Nastos, G.G., et al. Evidence-based sports supplements: A redox analysis. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.08.012 

Lastest Redox Preprints:

Hecht, F., Zocchi, M., Tuttle, E.T., et al. Catabolism of extracellular glutathione supplies amino acids to support tumor growth. BioRxiv (2024). https://doi.org/10.1101/2024.10.10.617667 

Cobley, J.N., Noble, A. & Guille, M. Cleland immunoblotting unmasks unexpected cysteine redox proteoforms. BioRxiv (2024). https://doi.org/10.1101/2024.09.18.613741 

Vorhauser, J., Roumeliotis, T. I., Leung, J. K., et al. Cell cycle-dependent S-sulfenyl proteomics uncover a redox switch in p21-CDK feedback governing the proliferation-senescence decision. BioRxiv (2024). https://doi.org/10.1101/2024.09.14.613007 

Moss, D. Y., Brown, C., Shaw, A., et al. Mitochondrial metabolism is a key determinant of chemotherapy sensitivity in Colorectal Cancer. BioRxiv (2024). https://doi.org/10.1101/2024.09.12.611189 

Rothemann, R.A., Pavlenko, E., Mondal, E., et al. Interaction with AK2A links AIFM1 to cellular energy metabolism. BioRxiv (2024). https://doi.org/10.1101/2024.09.09.611957 

Call for papers:

Journal: Free Radical Biology and Medicine

• Special Issue: Redox medicine: Translation of Basic science to the Clinic
• Submission deadline: 1 March 2025
• More information: https://www.sciencedirect.com/special-issue/314690/redox-medicine-translation-of-basic-science-to-the-clinic 

Redox Job Opportunities:

If there’s an open position in your lab for early career researchers and you would like to advertise it in our newsletter, just write us an email (ecr@sfrr-europe.org) containing the following information:

• Kind of position: (PhD student, Postdoc, etc)
• Research topic
• Institute/University
• Deadline
• Contact information
• Further information about the position (if any)

Dear colleagues,

ECR Editorial Mentoring Programme: call opened on 23rd September!

We are happy to announce the first edition of the new Editorial Mentoring Programme.
It is a programme that aims to offer ECRs the opportunity to increase their engagement with scientific publishing (SFRR-Europe official journals) and gain experience in editorial board work and manuscript handling. The programme will run over the year 2025 for 12 months. Selected participants will be paired with one of the Editorial Board members of one of SFRR-Europe's official journals and will receive 1 to 1 training and mentoring.

Further information about the application process and selection criteria can be found in the member’s intranet of the SFRR-E website: https://intranet.sfrr-europe.org

The call opened on the 23rd September and the deadline is on the 18th October.

We believe it’s an incredible opportunity for ECRs and hope that many of you will apply!

Second Edition of the PhD Redox Relay Online Symposium - call opens in October!

We are preparing the second edition of the PhD symposium. If you are a PhD student and would like to show the results of your project to the redox community, you can’t miss this call.

The format consists of online flask-talks of 5 minutes for presentation and 2 minutes for Q&A.

The call will open in the beginning of October, the deadline will be on the 15th October. Selected participants will be notified by the 25th October. The PhD Symposium will take place online on the 19th November.

It’s a great opportunity for PhD students to present their work and get valuable feedback.

Travel awards to attend the SFRR-I Galway Meeting 2025 - call already open!

If you enjoyed SFRR-E Meeting this year in Istanbul as much as we did, you can’t miss next year’s meeting! It will be a great opportunity for sharing your work and for networking because next year, the SFRR-E will be organising the SFRR-I biennial meeting, which means a lot of researchers from outside Europe will be attending.

Who can apply?

Students or postdocs members of SFRR-E.

To which awards can I apply?

• • Travel awards of 400€ each for PhD students
  • Travel awards of 400€ each for postdocs (less than 5 years after your PhD and not in permanent academic positions).
  • Travel awards of 900€ for non-European students or postdocs who require transoceanic or long-distance travel to attend the meeting. (You can also apply to this if you are a member of a SFRR Regional Society).

How to apply?

Applicatoins should be submitted online through the SFRR-E intranet (https://intranet.sfrr-europe.org, Call for Travel Awards in the menu on the left) as a single PDF containing:

• • CV (max 2 pages, include date of PhD award if applicable).
  • Supporting letter writteng by the aplicant (outlining your interest and motivation for attending the meeting)
  • Abstract for the communciation to be presented at the conference.

Important dates:

The deadline to recive submissions is on 10th January 2025.

Announcement of the awardees: before early-bird registration.

Applicant must submit their abstracts online thought the conference website (https://www.sfrrgalway2025.com) before 10^th February 2025.

If you need further information, you can contact info@sfrr-europe.org.

More information about the ECR Subcommittee can be found on the SFRR-E website ( ECR Committee (sfrr-europe.org ), while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: ecr@sfrr-europe.org.

Hope to see you online for our next Webinar Series appointment,

The ECR subcommittee

Upcoming events:

HNE Club Meeting

• • Lipid Oxidation: New Biochemical Insights and Clinical Applications
  • 10 - 12 October 2024
  • Location: Genoa, Italy
  • Further information: https://www.sfrr-europe.org/media/attachments/2024/03/07/new_hne_flyer.pdf

11th Biennial Meeting of the Society for Free Radical Research-Asia (SFRR-Asia 2024) Club Meeting

“The new era of precision redox biology and medicine: from basic research to the intervention of aging and diseases”

• • 21 - 23 October 2024
  • Location: Beijing, China
  • Deadlines:
    • Abstract submission: already closed
    • Early registration: 15 September 2024
  • Further information: https://sfrr-asia2024.tiemeeting.com/EN

SfRBM 2024 Conference

• • 31st Annual Conference
  • 20 - 23 November 2024
  • Location: Savannah, Georgia, USA
  • Deadlines:
    • Abstract and Awards Deadline: already closed
    • Early Registration Deadline: 15 October 2024
  • Further information: https://sfrbm.org/meetings/sfrbm-2024/

22nd SFRRI Biennial Meeting

• • The New Era of Redox Biology: from Basic Biochemistry to Redox Omics
  • 3 - 6 June 2025
  • Location: Galway, Ireland
    • Deadlines:
    • Travel Grant Applications: 10 January 2025
    • Abstract Submission: 10 February 2025
    • Early Bird Registration: 31 March 2025
  • Further information: https://www.sfrrgalway2025.com

Interesting Redox Papers:

Asantewaa, G., Tuttle, E.T., Ward, N.P., et al. Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nat Commun (2024). https://doi.org/10.1038/s41467-024-50454-2

Esteban-Collado, J., Fernández-Mañas, M., Fernández-Moreno, M., et al. Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration. EMBO J (2024). https://doi.org/10.1038/s44318-024-00155-9

Schwab, A., Rao, Z., Zhang, J., et al. Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition. Nat Cell Biol (2024). https://doi.org/10.1038/s41556-024-01464-1

Bonetti, L., Horkova, V., Grusdat, M., et al. A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation. Cell Metab (2024). https://doi.org/10.1016/j.cmet.2024.06.010

Lorito, N., Subbiani, A., Smiriglia, A., et al. FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer. EMBO Mol Med (2024). https://doi.org/10.1038/s44321-024-00090-6

Insightful Redox Reviews:

Furrer, R. & Handschin, C. Molecular aspects of the exercise response and training adaptation in skeletal muscle. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.07.026

Berndt, C., Alborzinia, H., Amen, V.S., et al. Ferroptosis in health and disease. Redox Biol (2024). https://doi.org/10.1016/j.redox.2024.103211

Akaike, T., Morita, M., Ogata, S., et al. New aspects of redox signaling mediated by supersulfides in health and disease. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.07.007

Nakamura, T. & Conrad, M. Exploiting ferroptosis vulnerabilities in cancer. Nat Cell Biol (2024). https://doi.org/10.1038/s41556-024-01425-8

Mialet-Perez, J. & Belaidi, E. Interplay between hypoxia inducible Factor-1 and mitochondria in cardiac diseases. Free Radic Biol Med (2024). https://doi.org/10.1016/j.freeradbiomed.2024.04.239

3) Sunrise Round Table I: Pillow Talks: From Academia to Industry (Thursday 6th June at 8:00, Hall 2).

On Thursday we began the morning with a sunrise round table, open for early birds and everybody who was not tired after a networking night.

Experts from academia (Antonio Cuadrado, Giuseppe Valacchi and Kasia Whysall) and industry (Mike Lu, Sven Terclavers and Carmen Veith) were there to discuss diverse career paths. Thank you all for the participation!

Everybody asked their questions about how it is working in either one of these sectors and it was very interesting knowing the pros and cons of each side. It is clear that career perspectives is a very important topic for ECRs and that many of you are very interested about this topic when you are at the end of your PhDs or while during your postdocs. For this reason we are planning on organising more events like that for ECRs!

4) Sunrise Round Table II: ROS Measurement: From Bedside to Bench (Friday 7th June at 8:00, Hall 2).

On Friday morning, we prepared a sunrise round table, open for everybody, focused on how to measure ROS. We were happy that many people joined, ECRs and not, considering also the early hour!

For this event we were honoured to have experts in ROS measurements (Michael Davies, Clare Hawkins, Giovanni Mann, Jan Riemer and Hadley D. Sikes). Our chairs (Veronica Lisi and Timoteo Marchini) organised a novel fishbowl set up which greatly helped to keep the dynamic of the event.

We were happy to see that how to measure ROS in an accurate way was such an important topic for you all, senior and not, and the very interesting debates originated during the round table.

5) ECR-Symposium: H2O2 on the Move: from Sub-cellular Redox Signals to Therapeutic Potential (Friday 7th June at 9:00, Hall 1).

On Friday morning, after the sunrise round table, we had our first symposium within the SFRR-E Annual Meeting organized only by ECRs. The symposium was chaired by Cristina Mas-Bargues and Carmen Veith. David Heppner, Rut Espinosa, Carlos Henriquez Olguin and Carmen Veith discussed a lot about NADPH oxidases in different contexts and diseases as well as subcellular hydrogen peroxide compartmentalization.

It was great seeing so many people at the symposium, interested in the work of our invited speakers. We deeply believe that it is inspirational for ECRs seeing the work of their peers at similar stages of their careers.

We also got to acknowledge the young researchers that presented great science at the meeting. The SFRR-E gave 6 awards to Irene Canovas-Cervera (Spain), Javier Marques (Spain), Ufuk Ersoy (UK), Attila Altinpinar (UK), Lea Strohm (Germany) and Konstantinos Papanikolaou (Greece). Congratulations to all the awardees!!

We had an incredible time together during the SFRR-E conference and it was very motivating seeing so many people enjoying our events and helping us build an ever growing community of young redox researchers!

The ECR subcommittee says a big THANKS! to everybody who attended our events, see you next year in Galway between 3 - 6 June 2025! You can already find details about the 2025 meeting in https://www.sfrrgalway2025.com.

More information about the ECR Subcommittee can be found on the SFRR-E website (ECR Committee (sfrr-europe.org), while regular updates can be found on Twitter (@SFRR_Europe), Instagram (@sfrr_ecr) and LinkedIn (SFRR-E). For any question or suggestion you might have, you can contact us via email: ecr@sfrr-europe.org.

Stay tuned for the next newsletter, it will be full with new information for ECRs!

The ECR subcommittee

The SFRR-E ECR committee with support from the SFRR-E, the SFRR-E official journals and Elsevier is delighted to announce the launch of a new ECR editorial mentoring programme.

The aim of the programme is to offer Early Career Researchers (ECRs) the opportunity to increase their engagement with scientific publishing and gain experience in editorial board work and manuscript handling.

The programme will run over the year 2025 for 12 months. Selected participants will be paired with one of the Editorial Board members of one of SFRR-Europe's official journals (i.e. Free Radical Biology and Medicine, Redox Biochemistry and Chemistry, and Redox Biology). They will receive 1:1 training and mentoring in:

• Assessing the suitability of a manuscript for consideration in the journal.

• Identification of potential reviewers.

• Assessing reviewer comments.

• Details concerning decision-making and preparation of a decision letter.

• Identification of ethical/policy questions that may arise with manuscripts submitted to the journals.

• Learning important aspects to consider when acting as an ambassador of a journal (e.g. suggestion of topics/authors for special issues, promotion of the journal at conferences/events and diffusion in social media).

Further information about the application process and selection criteria can be found in the member’s intranet of the SFRR-E website https://intranet.sfrr-europe.org. The application document should be uploaded as a single pdf on the intranet. 

Deadline for applications: 18th October 2024

If you have any further questions please contact: ecr@sfrr-europe.org

Dear colleagues,

We are pleased to announce the call for SFRR-E travel awards for students and postdocs to attend the 2025 biennial meeting of SFRR-I that will be organised by SFRR-E and held in Galway, Ireland, from 3 - 6 June 2025.

Please note that previous SFRR-E travel grant awardees and SFRR-E Young Investigator Award recipients, who have been supported to attend the SFRR-E annual conference previously, are not eligible to apply.

• Travel awards of 400 Euros each for PhD students members of SFRR-E.

• Travel awards of 400 Euros each for postdoc members of SFRR-E, who are less than 5 years post-PhD (excluding career disruption) and not in permanent academic positions.

• Travel awards of 900 Euros each for non-European students or postdoc members of SFRR-E or a SFRR Regional Society (with the same conditions as above), who require transoceanic or long-distance travel to attend the forthcoming Annual Meeting.

The number of travel awards for European PhD students, European post-docs, and international junior researchers will be decided after the evaluation process taking into account the scientific quality of the proposals.

The applications should be submitted online through the SFRR-E website https://intranet.sfrr-europe.org as a single PDF file containing a CV (max. 2 pages), which includes the date of PhD award, a supporting letter written by the applicant, outlining your interest and motivation for attending the conference, and an abstract for the communication to be presented during the conference.

As registered user of the SFRR-E intranet you will have access to submit your application when you login into the website https://intranet.sfrr-europe.org and select the option “Call for Travel Awards for SFRR-I Galway 2025” in the menu on the left.

The deadline to receive submissions is 10th January 2025. The decision about awardees will be announced before the early-bird registration deadline and the corresponding funds will be transferred to the awardees soon after this announcement.

PLEASE NOTE: applicants MUST submit their abstracts online through the conference website before 10TH February 2025, which is the deadline for abstract submission, and provide evidence of registration, to receive the travel funds.

Conference website: https://www.sfrrgalway2025.com

Please contact info@sfrr-europe.org should you need further information.

Dear colleagues,

We are inviting the submission of Symposium proposals for the next biennial meeting of SFRR-International, which will be organized by SFRR-E and held in Galway, Ireland from June 3-6, 2025.

Please submit your Symposium proposal using the template provided through the SFRR-E web site (www.sfrr-europe.org) before the deadline of 20th September 2024.

Current SFRR-E members will be able to submit Symposium proposals after they login into the intranet via the SFRR-E website, by choosing the “Symposium proposal” option in the menu on the left-hand side.

Members of other regional societies affiliated with SFRR-I can create a profile on the SFRR-E intranet by selecting the regional society to which they belong, when registering on the SFRR-E intranet to submit the documents. Click on “NEW USER registration” and select your affiliated society via the drop-down menu.

Symposium proposals should be submitted as a single pdf file using the template available on the SFRR-E website. Your proposal should include a summary of the novelty of the symposium and potential sources of sponsorship (max. 300 words), the names, full address, URLs for two Chairs, one of them also participating as speaker, as well as the names, full address, and URLs for 2 additional international speakers (+2-3 reserves and their addresses). In addition, please include provisional lecture titles and abbreviated CVs for the speakers (max. 300 words) and up to 5 selected publications for each one. The inclusion of an early career academic and gender balance/diverse speakers is required.

An International Scientific Committee will evaluate all Symposium proposals.

Three nights of accommodation, social events, and registration fees for invited speakers and chairs will be provided by SFRR-E.

More information is available on the SFRR-E website: SFRR International biennial meeting 2025

With best wishes,

Katarzyna Whysall
Chair of the Organizing Committee

Juan Sastre
President, SFRR-Europe

Giuseppe Valacchi
President-Elect, SFRR-Europe

Giovanni Mann
President of SFRR-International

Dear colleagues,

We are inviting the submission of nominations for the following SFRR-E honorary lectures to be presented at the SFRR-I Biennial Meeting 2025, which will be organized by SFRR-E and will take place in Galway, Ireland on the 3^rd - 6^th June 2025.

• SFRR-E Annual Award Lecture
• SFRR-Europe Basic Science Award Lecture
• SFRR-E Catherine Pasquier Memorial Lecture
• SFRR-E Leopold Flohé Redox Pioneer Young Investigator Award

Only current members of SFRR-E are able to submit nominations for special lectures, and must login into the member area of the SFRR-E website (https://www.sfrr-europe.org) and select the option “Call for Honorary Lectures for SFRR-I Galway Meeting 2025” in the menu on the left. Nominations should be submitted before or by the deadline of 20^th September 2024 as a PDF file using the word templates available on the SFRR-E website. Please find enclosed the guidelines for these honorary lectures.

An International Scientific Advisory Board will evaluate all nominations and the SFRR-E Executive will then select nominees with the highest rankings. 

More information is available on the SFRR-E website: SFRR International biennial meeting 2025

Thank you for your active collaboration with SFRR-E.

Best regards,
Clare Hawkins
General Secretary of SFRR-Europe

Dear colleague:

The SFRRI Executive is keen to receive nomination(s) for the next SFRRI President-Elect to take up their position in January 2025, as highlighted in the enclosed file and in the available link: https://sfrr.org/admin/files/uploads/call-for-nominations-for-sfrr-international-president-elect-31-07-24.pdf

The SFRR-I Executive is also seeking norminations from regional societies for the 2025 SFRRI Trevor Slater, Lester Packer, Alberto Boveris and Kelvin & Joanna Rising Star Award Lectures to be given at the 22nd SFRRI Meeting in Galway.

For further information on guidelines for nominating colleagues for the SFRRI Award Lectures 2025 and for the proposal of symposia see https://www.sfrr-europe.org/index.php/meetings/sfrr-international-biennial-meeting-2025.

Best wishes,
Juan Sastre
President of SFRR-Europe

SFRR-International are seeking nominations for their 2025 award lectures, to be given at the 22nd SFRR-International Meeting (hosted by SFRR-Europe) at the University of Galway, Ireland 3-6 June 2025. Further information about the meeting is available at the conference website: https://www.sfrrgalway2025.com

An overview of each award is provided below.

More detailed information about the nomination process, and supporting documentation required to submit a nomination for individual awards can be found here: SFRR International biennial meeting 2025 (sfrr-europe.org)

The deadline for receipt of nominations by email is 20 September 2024.

Nominations should be sent as a single PDF file to Patricia I. Oteiza (Email: poteiza@ucdavis.edu).

Trevor Slater Award Lecture

The Trevor Slater Award is the highest award of SFRR – International and is awarded on a biennial basis to a scientist who, in the judgment of the International Scientific Committee, has made an outstanding contribution to the field. It was set up in memory of Trevor Slater, a founder and first President of the Society. The award consists of a medal and certificate, and it is a requirement that the recipient presents a lecture at the Biennial meeting where the award is made and subsequently contributes an invited Review Article to Free Radical Biology & Medicine.

Lester Packer Award Lecture

The Lester Packer Award Lecture was established in 2021 in honor of Lester Packer, who edited more than 100 books and published over 800 articles that generated more than 33,000 citations.

The SFRR – International Lester Packer Award Lecture is awarded on a biennial basis to a scientist who, in the judgment of the International Scientific Committee, has made seminal contributions to the field redox biology and nutrition. The award consists of a medal and certificate, and it is a requirement that the recipient presents a lecture at the Biennial meeting where the award is made and subsequently contributes an invited Review Article to Free Radical Biology & Medicine.

Alberto Boveris Award Lecture

The Alberto Boveris Award Lecture was established in 2022 in honor of Alberto Boveris and will be awarded on a biennial basis to a scientist who, in the judgment of the International Scientific Committee, contributed significantly to the field of redox signaling. Alberto Boveris was instrumental in the discovery and characterization of the sites of superoxide production in mitochondria pivotal for the understanding of the metabolism of oxygen by mammalian cells. The award consists of a medal and certificate, and it is a requirement that the recipient presents a lecture at the Biennial meeting where the award is made and subsequently contributes an invited Review Article to Free Radical Biology & Medicine.

Kelvin and Joanna Davies Rising Star Award

The Kelvin and Joanna Davies Rising Star Award is intended to recognize an emerging leader in the Free Radical/Redox Biology field, whose record reflects ongoing and exceptional scientific growth and contributions to our body of knowledge, and increased levels of leadership, responsibility and sphere of impact. Awardees must hold an earned doctoral degree, have completed postdoctoral training, and be in the first six years of a tenure-track appointment, or equivalent. While eligible nominees will have not yet reached a senior-level position, their track record must reflect a strong career trajectory with the probability of forward advancement and potential for appointment at the highest levels.

The names of previous awardees for each award other general information is available from: https://www.sfrr.org

Applications are open for SFRR-Europe Visiting Fellowships for 2024. Awards of up to €2000 will be made to Early Career Investigators to cover travel and accommodation expenses for a short research stay [minimum 3 weeks] in another European laboratory, to be completed before June 2025. The number of awards made will be determined by the quality of the submitted proposals.

Applicants should submit a single PDF containing:

1. a brief summary of the research project (maximum one A4 page) stating the expected duration, budget, rationale and expected outcomes from the short stay.

2. CV (maximum 2 A4 pages) of the applicant including date of birth, date of PhD award (if applicable), current position and a list of publications.

3. abbreviated CVs of both the home and proposed host supervisors (maximum 2 A4 pages each).

4. a letter from the host institution agreeing to host and provide facilities for the visitor.

Previous awardees of Early Career Researcher (ECR) Fellowships or Visiting Fellowships are not eligible.

Applications should be submitted by logging-in to the SFRR-E intranet (https://intranet.sfrr-europe.org) and selecting the call for SFRR-E VISITING FELLOWSHIPS 2024. Applications which do not adhere to the above requirements, will not be considered.

The deadline for applications is 15 May 2024, and the results will be announced at the General Assembly of SFRR-E, held during the SFRR-Europe Annual Meeting in Istanbul, 4-7 June 2024.

Requirements for the applicant:

• Under 35 years of age and without a permanent university position

• Member of SFRR-Europe

• Presentation of a brief written report, and details of expenditure, to the SFRR-Europe Executive one month after the research visit. The report may be posted on the SFRR-Europe website.

Requirements for the supervisors at the home and host institutions:

• Both the home and host supervisors must be members of SFRR-Europe

We are inviting the submission of symposia proposals and nominations for the following SFRR-E honorary lectures to be presented at the SFRR-E Meeting 2024 “From Molecules to Tissues: Redox Biology in Action”, which will take place in Istanbul, Turkey on the 5^th - 7^th June 2024.

Conference website: https://redoxistanbul2024.com

• SFRR-E Annual Award Lecture
• SFRR-Europe Basic Science Award Lecture
• SFRR-Europe Clinical Science Award Lecture
• SFRR-E Catherine Pasquier Memorial Lecture
• SFRR-E Leopold Flohé Redox Pioneer Young Investigator Award

Only current members of SFRR-E are able to submit symposium proposals or nominations for special lectures, and must login into the member area of the SFRR-E website intranet.sfrr-europe.org and select the relevant option "Call for symposia for SFRR-E Istanbul Meeting 2024" or “Call for Honorary Lectures for SFRR-E Istanbul Meeting 2024” in the menu on the left.

Symposia proposals and lecture nominations should be submitted before or by the deadline of 6^th October 2023 as a PDF file using the word templates available when you log in to the member area of the SFRR-E website. Please find enclosed the guidelines for these honorary lectures.

An International Scientific Advisory Board will evaluate all proposals and nominations and the SFRR-E Executive will then select those with the highest rankings.

Thank you for your active collaboration with SFRR-E.

We are excited to announce the new recipients of the SFRR-E Honorary Lecture Awards, which will be presented during the Annual meeting, to be held in Istanbul, Turkey from 5-7 June, 2024. Congratulations to the awardees!

SFFR-E Annual Award Lecture
Anna Maria Cuervo
Albert Einstein College of Medicine, United States
Title: Selective autophagy in the fight against aging and age-related diseases

SFRR-E Basic Science Award Lecture (Sponsored by Elsevier)
Kelvin Davies
University of Southern California, Los Angeles, USA
Title: The Redox Biology of Adaptive Homeostasis

SFFR-E Clinical Science Award Lecture (Sponsored by SFRR-E and OCC)
Thomas Michel
Harvard University, USA
Title: Novel chemogenetic/transgenic models of tissue-specific oxidative stress

Catherine Pasquier Award Lecture
Eduardo Fuentes-Lemus
University of Copenhagen, Denmark
Title: Macromolecular crowding in the context of redox biology: effects on protein oxidation and aggregation

Leopold Flohe Award Lecture
Jose Luis Garcia Giménez
Universitat de Valencia, Spain
Title: When epigenetics meets the redox regulation and signaling

Join our Mentoring Program

Earlier this year, the Society for Free Radical Research Europe has introduced a new subcommittee dedicated to early career researchers, the ECR Subcommittee. The Subcommittee aims to create a vibrant ECR community within the SFRR-E devoted to young investigators' education and visibility.
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